Annuaire du laboratoire :
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Après un diplôme de chimie et technologie pharmaceutique obtenu en 2005, le Dr. Simona Mura a obtenu sa thèse en 2009 sous la direction du Prof. Anna Maria Fadda à l’Université de Cagliari (Italie), où elle a étudié des systèmes colloïdaux pharmaceutiques pour l’administration topique de médicaments. Elle a ensuite effectué un post-doc dans le groupe du Prof. Elias Fattal à l’Institut Galien Paris-Sud (UMR CNRS 8612), Faculté de Pharmacie de Châtenay-Malabry (France), portant sur l’étude de la toxicité de nanoparticules biodégradables destinées à l’administration pulmonaire. En 2011, elle a été nommée Maître de Conférences dans le cadre du programme « Chaires CNRS-Enseignement supérieur », et a intégré l’équipe du Prof. Patrick Couvreur à l’Institut Galien Paris-Sud. Depuis 2015, elle est également Professeure invitée à l’Université d’Osaka (Japon). Ses activités de recherche portent sur la conception de vecteurs pour la délivrance de médicaments biomimétiques ainsi que sur la construction de modèles in vitro et in vivo pour l’évaluation de l’efficacité thérapeutique de nouveaux nanomédicaments pour le traitement de maladies néoplasiques sévères. Elle est co-autrice de 38 publications dans des journaux à comité de lecture, de 4 chapitres d’ouvrage et coéditrice d’un ouvrage. Elle a également été nommée membre junior de l’Institut Universitaire de France en 2017.
Dr. Simona Mura gained the degree in Pharmaceutical Chemistry and Technology in 2005. In 2009, she was awarded her PhD in Chemistry and Technology of Drug at the University of Cagliari, Italy, working on the design and in vitro evaluation of novel vesicular systems for the topical delivery of drugs. In 2008 she joined the group of Pr. Elias Fattal at Institut Galien Paris-Sud (UMR CNRS 8612), Faculté de Pharmacie de Châtenay-Malabry (France), as a post-doctoral research assistant to study the lung toxicity of biodegradable nanoparticles designed for pulmonary administration of drugs. In 2011 she was appointed Associate Professor within the framework of the « CNRS-Higher Education chairs » program at Institut Galien Paris-Sud in the group of Prof. Patrick Couvreur. Since 2015 she is also Associate visiting professor at the Univeristy of Osaka (Japan). Her research focuses on the design of biomimetic drug delivery systems and the construction of in vitro and in vivo models for a relevant the assessment of the therapeutic efficacy of nanoscale drug delivery systems for the treatment of severe neoplastic diseases. She is (co)author of 38 peer review articles in international journals, 4 book chapters and co-editor of 1 book. Simona has also been appointed Junior member of the Institut Universitaire de France (IUF) in 2017
Mots clés
Nanoparticules ; prodrogues ; cancer ; lipoprotéines ; culture cellulaire en trois dimensions ; modelés 3D de cancer
Nanoparticles; prodrugs ; cancer ; lipoproteins ; three dimensional cell culture methodologies ; 3D tumor models
10 publications majeures
- Sobot, D.; Mura, S.; Yesylevskyy, S.; Dalbin, L.; Cayre, F.; Bort, G.; Mougin, J.; Desmaële, D.; Lepetre-Mouelhi, S.; Pieters, G.; Andreiuk, B.; Klymchenko, A.S.; Paul, J.L.; Ramseyer, C.; Couvreur P.* Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery. Nat. Comm. 2017, DOI: 10.1038/ncomms15678
- Sobot, D.; Mura, S.; Rouquette, M.; Vukosavljevic, B.; Cayre, F.; Buchy, E.; Pieters, G.; Garcia-Argote, S.; Windbergs, M.; Desmaële, D.; Couvreur, P.* Circulating lipoprotein: a Trojan horse guiding squalenoylated drugs to LDL-accumulating cancer cells. Mol. Therapy 2017, 25(7):1596-1605
- Lazzari, G. ; Couvreur, P. ; Mura, S.*. Multicellular tumor spheroids: a relevant 3D model for in vitro preclinical investigation of polymer nanomedicines. Polym. Chem. 2017, 8, 4947 4969
- Cayre, F.; Mura, S.;* Andreiuk, B.; Sobot, D.; Gouazou, S.; Desmaële, D.; Klymchenko, A.S.; Couvreur, P.* In vivo FRET imaging to predict the risk associated with hepatic accumulation of squalene-based prodrug nanoparticles.Adv. Healthc. Mat. 2017, doi:10.1002/adhm.201700830
- Valetti, S.; Maione, F.; Mura, S.; Stella, B.; Desmaële, D.; Noiray, M.; Vergnaud, J.; Vauthier, C.; Cattel, L., Giraudo, E.; Couvreur, P.* Peptide-functionalized nanoparticles for selective targeting of pancreatic tumor.J. Control. Release 2014, 192, 29-39
- Mura, S.;* Zouhiri, F.; Lerondel, S.; Maksimenko, A.; Mougin, J.; Brambilla, D.; Caron, J.; Sliwinski, E.; LePape, A., Desmaële, D.; Couvreur P.* Novel isoprenoyl nanoassembled prodrug for paclitaxel delivery.Bioconjug. Chem. 2013, 24 (11), 1840-1849
- Mura, S.; Nicolas, J.; Couvreur, P.* Stimuli-Responsive Nanocarriers for Drug Delivery. Nature Mater. 2013, 12, 991
- Le Droumaguet, B.; Nicolas, J.;* Brambilla, D.; Mura, S.; Maksimenko, A.; De Kimpe, L.; Salvati, E.; Zona, C.; Airoldi, C.; Canovi, M.; Gobbi, M.; Noiray, M.; La Ferla, B.; Nicotra, F.; Scheper, W.; Flores, O.; Masserini, M.; Andrieux, K.; Couvreur, P. Versatile and Efficient Targeting from a Single Nanoparticulate Platform: Application to Cancer and Alzheimer’s Disease. ACS Nano 2012, 6, 5866
- Maksimenko A.; Mougin J.; Mura S.; Sliwinski E.; Lepeltier E.; Bourgaux C.; Lepêtre S.; Zouhiri F.; Desmaële D.; Couvreur P.; Polyisoprenyl gemcitabine conjugates self-assemble as nanoparticles useful for cancer therapy. Cancer Letters. 2013, 334(2), 346-353
- Mura S.; Hillaireau H.; Nicolas, J.; Kerdine Romer S.; Le Droumaguet B.; Delomenie C.; Pallardy M.; Tsapis N.; Fattal E.. Biodegradable nanoparticles meet the bronchial airway barrier: how surface properties affect their potential in vitro toxicity. Biomacromolecules. 2011, 12, 11, 4136-4143
- Frédéric Lirussi, Kyrylo Pyrshev, Semen Yesylevskyy, Timothée Rivel, Tatiana Lopez, et al.. Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2023, 1869 (2), pp.166614. ⟨10.1016/j.bbadis.2022.166614⟩. ⟨hal-04226778⟩
- Martina Ugrinic, Dominique Decanini, Nadège Bidan, Gianpiero Lazzari, Abdelmounaim Harouri, et al.. Fabrication of high aspect ratio microfluidic devices for long term in vitro culture of 3D tumor models. Microelectronic Engineering, 2023, 267-268, pp.111898. ⟨10.1016/j.mee.2022.111898⟩. ⟨hal-03832911⟩
- Alban Guesdon Vennerie, P Couvreur, Fatoumia Ali, Frederic Pouzoulet, Christophe Roulin, et al.. Breaking photoswitch activation depth limit using ionising radiation stimuli adapted to clinical application. Nature Communications, 2022, 13, pp.4102. ⟨10.1038/s41467-022-30917-0⟩. ⟨hal-03737235⟩
- Nadege Bidan, Sainza Lores, Aure Vanhecke, Valérie Nicolas, Severine Domenichini, et al.. Before in vivo studies: In vitro screening of sphingomyelin nanosystems using a relevant 3D multicellular pancreatic tumor spheroid model. International Journal of Pharmaceutics, 2022, ⟨10.1016/j.ijpharm.2022.121577⟩. ⟨hal-04348370⟩
- Eleonore Coppens, Didier Desmaële, Timothée Naret, Sébastien Garcia-Argote, Sophie Feuillastre, et al.. Gemcitabine lipid prodrug nanoparticles: switching the lipid moiety and changing the fate in the bloodstream. International Journal of Pharmaceutics, In press, 609, pp.121076. ⟨10.1016/j.ijpharm.2021.121076⟩. ⟨hal-03375569⟩
- Hassan Rammal, Almar Al Assaad, Franco Dosio, Barbara Stella, Andrei Maksimenko, et al.. Investigation of squalene-doxorubicin distribution and interactions within single cancer cell using Raman microspectroscopy. Nanomedicine: Nanotechnology, Biology and Medicine, 2021, 35, pp.102404. ⟨10.1016/j.nano.2021.102404⟩. ⟨hal-03406418⟩
- Eleonore Coppens, Didier Desmaele, Julie Mougin, Sandrine Tusseau-Nenez, Patrick Couvreur, et al.. Gemcitabine Lipid Prodrugs: The Key Role of the Lipid Moiety on the Self-Assembly into Nanoparticles. Bioconjugate Chemistry, In press, 32 (4), pp.782-793. ⟨10.1021/acs.bioconjchem.1c00051⟩. ⟨hal-03189242⟩
- Vincent Pautu, Heng Zhao, Angelika Mielcarek, Anna Balasso, Patrick Couvreur, et al.. When drug nanocarriers miss their target: extracellular diffusion and cell uptake are not enough to be effective. Biomaterials Science, 2021, ⟨10.1039/D1BM00669J⟩. ⟨hal-04348418⟩
- C. Rodríguez-Nogales, S. Mura, P Couvreur, M.J. Blanco-Prieto. Squalenoyl-gemcitabine/edelfosine nanoassemblies: Anticancer activity in pediatric cancer cells and pharmacokinetic profile in mice. International Journal of Pharmaceutics, 2020, 582, pp.119345. ⟨10.1016/j.ijpharm.2020.119345⟩. ⟨hal-03490684⟩
- Alysia Cox, Daniele Vinciguerra, Francesca Re, Roberta Dal Magro, Simona Mura, et al.. Protein-Functionalized Nanoparticles Derived from End-Functional Polymers and Polymer Prodrugs for Crossing the Blood-Brain Barrier. European Journal of Pharmaceutics and Biopharmaceutics, 2019, 142, pp.70-82. ⟨10.1016/j.ejpb.2019.06.004⟩. ⟨hal-02323861⟩
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