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Myriam Taverna est Professeure en Biotechnologie pharmaceutique à l’Université Paris-Sud (Université Paris-Saclay, France) depuis 2005 et a occupé auparavant des fonctions de Maitres de conférences en chimie analytique à la faculté de pharmacie de l’Université Paris-Sud. En 2017 elle est nommée membre senior de l’institut Universitaire de France. Elle dirige actuellement une équipe de recherche composée de 16 chercheurs, qui se consacre au développement de techniques analytiques miniaturisées pour l’analyse de peptides, protéines qu’elles soient thérapeutiques, cibles de médicaments ou biomarqueurs de pathologie. Son activité de recherche s’appuie notamment sur les nanotechnologies, les microsystèmes d’analyse, l’électrophorèse capillaire et les méthodes séparatives ainsi que leur couplage à la spectrométrie de masse. Ses travaux de recherche dans le domaine des biomarqueurs de la maladie d’Alzheimer l’ont amenée à co-fonder en 2014 la start-up Alzohis dédiée au diagnostic de la maladie d’Alzheimer.

Myriam Taverna is Professor of Analytical Chemistry and Biotechnology at Paris-Sud University (Paris-Saclay University, France) since 2005 and senior member of the Institut Universitaire de France (IUF). She is currently leading a research team of 16 researchers, dedicated to the development of miniaturized analytical techniques for the analysis of peptides, protein being biotherapeutics, drug targets or biomarkers of pathology. Its research activity is mainly based on nanotechnologies, analytical microsystems, capillary electrophoresis and separation methods as well as their coupling to mass spectrometry. Her research work in the field of biomarkers of Alzheimer’s disease led her to co-found in 2014 the start-up Alzohis dedicated to the diagnosis of Alzheimer’s disease.

Mots clés

Electrophorèse capillaire, techniques d’analyse miniaturisée, microsystèmes d’analyse ; biomarqueurs de pathologies, maladies neurodégénératives

Capillary electrophoresis, miniaturized techniques; analytical microsystems, disease biomarkers, neurodegenerative diseases

10 publications majeures

• T.D. MAI, D. FERRARO, N. ABOUD, R. RENAUD, M. SERRA, N.T. TRAN, J.L. VIOVY, C. SMADJA, S. DESCROIX AND M. TAVERNA – Single-step immunoassays and microfluidic droplet operation: towards a versatile approach for detection of amyloid-ß peptide-based biomarkers of Alzheimer’s disease – Sensors and Actuators B: Chemical.2018,255, 2126-2135.
• BRINET D, GAIE-LEVREL F, DELATOUR V, KAFFY J, ONGERI S, TAVERNA M*.In vitro monitoring of amyloid ß-peptide oligomerization by Electrospray differential mobility analysis: An alternative tool to evaluate Alzheimer’s disease drug candidates. TALANTA 2017,165:84-91.
• S. PELLEGRINO, N. TONALI, E. ERBA, J. KAFFY, M. TAVERNA, A. CONTINI, M. TAVLOR, D. ALLSOP, M.L. GELMI, S. ONGERI : ß-Hairpin mimics containing a piperidine-pyrrolidine scaffold modulate the ß-amyloid aggregation process preserving the monomer species. Chemical Science 2017,8(2):1295-1302.
• ARAYA-FARIAS M, DZIOMBA S, CARBONNIER B, GUERROUACHE M, AYED I, ABOUD N, TAVERNA M, TRAN NT. A lab-on-a-chip for monolith-based preconcentration and electrophoresis separation of phosphopeptides. Analyst 2017,142(3):485-494.
• DZIOMBA S, ARAYA-FARIAS M, SMADJA C, TAVERNA M, CARBONNIER B, TRAN NT. Solid supports for extraction and preconcentration of proteins and peptides in microfluidic devices: A review. Anal Chim Acta. 2017,22;955:1-26.
• KAFFY J., BRINET D., SOULIER J.L., CORRELA I., TONALI N., FERA K., IACONE Y., HOFFMANN A., KHEMTEMOURIAN L., CROUSSE B., TAYLOR M., ALLSOP D. TAVERNA M., LEQUIN O., ONGERI S. Designed glycopeptidomimetics disrupt protein-protein interactions mediating amyloid ß-peptide aggregation and restore neuroblastoma cell viability. J. Med. Chem. 2016, 59(5), 2025-40.
• MARIE AL., DOMINGUEZ-VEGA E., SALLER F., PLANTIER J-L., URBAIN R., BORGEL D., TRAN N.T., GOVERT W. SOMSEN , TAVERNA M*. Characterization of conformers and dimers of antithrombin by capillary electrophoresis-quadrupole-time-of-flight mass spectrometry. Analytica Chimica Acta. 2016,947:58-65
• T.D. MAI, I. PEREIRO, M. HIRAOUI, J.L. VIOVY, S. DESCROIX, M. TAVERNA AND C. SMADJA – Magneto-immunocapture with on-bead fluorescent labelling of amyloid-ß peptides: towards a microfluidized-bed-based operation – Analyst.2015,140, 5891-5900.
• JACCOULET E, SMADJA C, PROGNON P, TAVERNA M. Capillary electrophoresis for rapid identification of monoclonal antibodies for routine application in hospital. Electrophoresis 2015,36,17: 2050-6.
• OUKACINE F. AND TAVERNA M. Suppression of Apparent Fluid Flow in Capillary Isotachophoresis without Recourse to Capillary Coating. Anal Chem. 2014,86(7):3317-22