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Laurence Moine a obtenu sa thèse portant sur la synthèse de polymères biodégradables à base de poly(acide malique) en 1998. Elle a ensuite effectué un stage post-doctoral de deux ans à l’Université de Strathclyde en Ecosse où elle a travaillé sur la synthèse de nouvelles résines acryliques pour la séparation de métaux précieux par chromatographie. En 2000, elle a obtenu un poste de Chargé de Recherche au CNRS et en 2004, elle a rejoint l’Institut Galien Paris-Sud (Univ. Paris-Sud) dans l’équipe du Prof. Elias Fattal. Son activité de recherche s’articule autour de deux axes principaux : 1) la préparation de matériaux particulaires biocompatibles dégradables pour l’embolisation thérapeutique et 2) la synthèse de nouveaux vecteurs polymères biodégradables pour l’adressage de molécules thérapeutiques vers un organe, un tissu ou une cellule malade.

Laurence Moine completed her PhD in 1998 under the supervision of Prof. Guérin and Prof. Amiel at the University of Paris XII where she studied the synthesis of poly (malic acid) biodegradable polymers. Then, she joined the group of Prof. Sherrington at the University of Strathclyde in Scotland for a two years post-doctoral internship to work on the synthesis of new acrylic resins for the separation of precious metals by liquid chromatography. In 2000, she obtained a CNRS researcher position in Bordeaux and in 2004 she joined the group of Prof. Elias Fattal at Institut Galien Paris-Sud (Univ. Paris-Sud) in Châtenay-Malabry (France). Her research activity is focused between two main axes: 1) the preparation of degradable materials for therapeutic embolization and 2) the synthesis of new biodegradable polymer vectors for the vectorization of therapeutic molecules.

Mots clés

Polymère dégradable, microsphère, nanoconjugué, embolisation

Degradable polymer, microsphere, nanoconjugate, embolization

10 publications majeures

• Deschamps F, Harris K.R, Moine L, Li W, Tselikas L, Isoardo T, Lewandowski R.J, Paci A, Huang N, de Baere T, et al. Pickering-Emulsion for Liver Trans-Arterial Chemo-Embolization with Oxaliplatin. Cardiovasc. Intervent. Radiol. 2018, 41(5):781–788.
• Houvenagel S, Moine L, Picheth G, Dejean C, Brûlet A, Chennevière A, Faugeras V, Huang N, Couture O, Tsapis N. Comb-Like Fluorophilic-Lipophilic-Hydrophilic Polymers for Nanocapsules as Ultrasound Contrast Agents. Biomacromolecules 2018, 19(8):3244–3256.
• Deschamps F, Moine L, Isoardo T, Tselikas L, Paci A, Mir L.M, Huang N, Fattal E, de Baère T. Parameters for Stable Water-in-Oil Lipiodol Emulsion for Liver Trans-Arterial Chemo-Eembolization. Cardiovasc. Intervent. Radiol. 2017, 40(12):1927–1932.
• Laurent A, Moine L. The New Biomaterials of Embolization: The Shift to Degradable. Med. Sci. (Paris). 2017, 33(1):25–31.
• Bédouet L, Moine L, Servais E, Beilvert A, Labarre D, Laurent A. Tunable Delivery of Niflumic Acid from Resorbable Embolization Microspheres for Uterine Fibroid Embolization. Int. J. Pharm. 2016, 511(1):253–261.
• Jubeli E, Yagoubi N, Pascale F, Bédouet L, Slimani K, Labarre D, Saint-Maurice J.P, Laurent A, Moine, L. Embolization Biomaterial Reinforced with Nanotechnology for an In-Situ Release of Anti-Angiogenic Agent in the Treatment of Hyper-Vascularized Tumors and Arteriovenous Malformations. Eur. J. Pharm. Biopharm. 2015, 96:396–408.
• Verret V, Pelage J.P, Wassef M, Louguet S, Servais E, Bédouet L, Beaulieu T, Moine L, Laurent A. A Novel Resorbable Embolization Microsphere for Transient Uterine Artery Occlusion: A Comparative Study with Trisacryl-Gelatin Microspheres in the Sheep Model. J. Vasc. Interv. Radiol. 2014, 25(11):1759–1766.
• Louguet S, Verret V, Bédouet L, Servais E, Pascale, F, Wassef M, Labarre D, Laurent A, Moine L. Poly(Ethylene Glycol) Methacrylate Hydrolyzable Microspheres for Transient Vascular Embolization. Acta Biomater. 2014, 10(3):1194–1205.
• Maeda, N, Verret V, Moine L, Bédouet L, Louguet S, Servais E, Osuga K, Tomiyama N, Wassef M, Laurent A. Targeting and Recanalization after Embolization with Calibrated Resorbable Microspheres versus Hand-Cut Gelatin Sponge Particles in a Porcine Kidney Model. J. Vasc. Interv. Radiol. 2013, 24(9):1391–1398.
• Jubeli E, Moine L, Nicolas V, Barratt G. Preparation of E-Selectin-Targeting Nanoparticles and Preliminary in Vitro Evaluation. Int. J. Pharm. 2012, 426(1–2):291–301.