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Julie Mougin est ingénieur diplômée de l’Ecole Nationale Supérieure de Chimie de Mulhouse (ENSMu) et titulaire d’un Master en formulation de systèmes colloïdaux et polymères. Elle a rejoint l’équipe du Prof. Patrick Couvreur au sein de l’Institut Galien Paris-Sud en 2010 an tant qu’Ingénieur d’Etudes. Ses travaux portent sur la caractérisation physico-chimique de nanomédicaments. Elle est actuellement en thèse dont le sujet porte sur la formulation et la caractérisation de nanoassemblages de prodrogues à base de squalène. Elle est co-autrice de 17 publications dans des journaux internationaux à comité de lecture.

Julie Mougin is an engineer who graduated from the National College of Chemical Engineering of Mulhouse (ENSMu) and holder of a Master’s degree specialized in formulation of colloids in polymers. She joins the group of Prof. Patrick Couvreur at Institut Galien Paris-Sud in 2010. Her activity is focused on the physico-chemical characterization of nanomedicines. She is also doing a PhD thesis whose topic is about the formulation and the characterization of squalene-based nanoassemblies. She is co-author of 17 publications in international peer-review journals.

Mots clés

nanoparticules ; prodrogues ; drug delivery ; physico-chimie ; squalène

nanoparticles ; prodrugs ; drug delivery ; physico-chemistry ; squalene

10 publications majeures

• Kotelevets, L.; Chastre, E.; Caron, J.; Mougin, J.; Bastian, G.; Pineau, A.; Walker, F.; Lehy, T.; Desmaële, D.; Couvreur, P.* A Squalene-Based Nanomedicine for Oral Treatment of Colon Cancer. Cancer Research 2017, DOI : 10.1158/0008-5472.CAN-16-1741
• Sobot, D.; Mura, S.; Yesylevskyy, S. O.; Dalbin, L.; Cayre, F.; Bort, G.; Mougin, J.; Desmaële, D.; Lepetre-Mouelhi, S.; Pieters, G.; Andreiuk, B.; Klymchenko, A. S.; Paul; J.-L.; Ramseyer, C.; Couvreur, P.* Conjugation of Squalene to Gemcitabine as Unique Approcah Exploiting Endogenous Lipoproteins for Drug Delivery. Nature Communications 2017, DOI : 10.1038/ncomms15678
• Gaudin, A.; Tagit, O.; Sobot, D.; Lepetre-Moulhi, S.; Mougin, J.; Martens, T. F.; Braeckmans, K.; Nicolas, V.; Desmaële, D.; De Smedt, S.; Hildebrandt, N.; Couvreur, P.;* Andrieux, K. Transport Mechanisms of Squalenoyl-Adenosine Nanoparticles Across the Blood-Brain Barrier. Chemistry of Materials 2015, DOI : 10.1021/acs.chemmater.5b00267
• Gaudin, A.; Lepetre-Moulhi, S.; Mougin, J.; Parrod, M.; Pieters, G.; Garcia-Argote, S.; Loreau, O.; Goncalves, J.; Chacun, H.; Courtebaisse, Y.; Clayette, P.; Desmaële, D.; Rousseau, B.; Andrieux, K.;* Couvreur, P. Pharmacokinetics, Biodistribution and Metabolism of Squalenoyl Adenosine Nanoparticles in Mice Using Radio-Labelling and Radio-HPLC Analysis. Journal of Controlled Release 2015, DOI : 10.1016/j.jconrel.2015.06.016
• Gaudin, A.; Yemisci, M.; Eroglu, H.; Lepetre-Moulhi, S.; Turkoglu, O. F.; Dönmez-Demir, B.; Caban, C.; Sargon, M. F.; Garcia-Argote, S.; Pieters, G.; Loreau, O.; Rousseau, B.; Tagit, O.; Hildebrandt, N.; Le Dantec, Y.; Mougin, J.; Valetti, S.; Chacun, H.; Nicolas, V.; Desmaële, D.; Andrieux, K.;* Capan, Y.; Dalkara, T.; Couvreur, P.* Squalenoyl Adenosine Nanoparticles Provide Neuroprotection After Stroke and Spinal Cord Injury. Nature Nanotechnology 2014, DOI : 10.1038/nnano.2014.274
• Mackiewicz, N.; Nicolas, J.;* Handké, N.; Noiray, M.; Mougin, J.; Daveu, C.; Reddy, L. H.; Bazile, D.; Couvreur, P. Precise Engineering of Multifunctional PEGylated Polyester Nanoparticles for Cancer Cell Targeting and Imaging. Chemistry of Materials 2014, DOI : 10.1021/cm403822w
• Maksimenko, A.; Alami, M.; Zouhiri, F.; Brion, J.-D.; Pruvost, A.; Mougin, J.; Hamze, A.; Boissenot, T.; Provot, D.; Desmaële, D.; Couvreur, P.* Therapeutic Modalities of Squalenoyl Nanocomposites in Colon Cancer: an Ongoing Search for Improved Efficacy. ACS Nano 2014, DOI : 10.1021/nn500517a
• Maksimenko, A.; Dosio, F.; Mougin, J.; Ferrero, A.; Wack, S.; Reddy, L. H.; Weyn, A.-A.; Lepeltier, E.; Bourgaux, C.; Stella, B.; Cattel, L.; Couvreur, P.* A Unique Squalenoylated and Nonpegylated Doxorubicine Nanomedicine with Systemic Long-Circulating Properties and Anticancer Activity. Proceedings of the National Academy of Sciences 2014, DOI : 10.1073/pnas.1313459110
• Harrisson, S.; Nicolas, J.;* Maksimenko, A.; Bui, D. T.; Mougin, J.; Couvreur, P. Nanoparticles with In Vivo Anticancer Activity from Polymer Prodrug Amphiphiles Prepared by Living Radical Polymerization. Angewandte Chemie 2013, DOI : 10.1002/anie.201207297
• Maksimenko, A.; Mougin, J.; Mura, S.; Sliwinski, E.; Lepeltier, E.; Bourgaux, C.; Lepetre-Moulhi, S.; Zouhiri, F.; Desmaële, D.; Couvreur, P.* Polyisoprenoyl Gemcitabine Conjugates Self Assemble as Nanoparticles, Useful for Cancer Therapy. Cancer Letters 2013, DOI : 10.1016/j.canlet.2012.08.023