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Jean-Philippe Michel est enseignant-chercheur (MCU HC, HDR) à l’Université Paris Sud (COMUE Université Paris-Saclay) depuis 2007. Physicien de formation, il a obtenu un D.E.A. en physique statistique, puis un doctorat en 2002 portant sur l’étude de la structure de films minces de cristal liquide en phase smectique et frustrés sur un substrat monocristallin. Ses activités de recherche portent sur la conception et la caractérisation de modèles membranaires formés à différentes interfaces (air/liquide, solide/liquide et liquide/liquide) afin de comprendre les interactions entre les membranes de cellules cancéreuses et les molécules photosensibles conçues pour le traitement du cancer par photothérapie dynamique. Depuis 2010, il a étendu cette approche à l’étude de peptides antimicrobiens et la modélisation des membranes bactériennes afin de mieux comprendre leurs relations structure-activité. Il a acquis une expertise dans le domaine des modèles membranaires construits à différentes interfaces, de l’analyse physico-chimique des interactions avec les modèles membranaires biomimétiques et de la caractérisation des biomatériaux par microscopie à sonde locale, de la diffraction des rayons X et de la réflectivité neutronique. Plus récemment, il étudie l’impact de la fonctionnalisation de peptides antimicrobiens courts, linéaires et cationiques avec des chaînes d’acides gras de différente longueur sur leur activité antimicrobienne ainsi que sur leur mécanisme d’action de lyse des membranes bactériennes.

Dr. Jean-Philippe Michel (MCF HC, HDR) is associate professor at the University of Paris Sud (COMUE Université Paris-Saclay) since 2007. After basic physics studies at Paris 7 university, he obtained a D.E.A. in Statistical Physics in 1999, then a Ph.D. in 2002 studying the structure of thin liquid crystal films in the smectic phase and frustrated on a monocrystalline substrate. His research activities hold on the conception and characterization of different membrane model systems formed at different interfaces (air/liquid, solid/liquid and liquid/liquid) to understand the physics of the interactions existing between biological cancer cell membranes and photosensitive molecules designed for cancer treatment. Since 2010, he is studying antimicrobial peptides and the modeling of bacterial membranes to better understand their structure-activity relationships. He has acquired expertise in the field of membrane models built at various interfaces, physico-chemical analysis of interactions with biomimetic membrane models and characterization of biomaterials by local probe microscopies, X-ray diffraction and neutron reflectivity. More recently, he functionalized short linear cationic antimicrobial peptides with fatty acid chains in order to understand the impact of such functionalization on their antimicrobial activity and their mechanism of lytic action against bacterial membranes.

Mots clés

Modèles membranaires biomimétiques; interactions molécule-membrane ; peptides antimicrobiens ; relation structure-activité ; biophysique membranaire

Biomimetic membrane models; molecule-membrane interactions; antimicrobial peptides; structure-activity relationship; membrane biophysics

10 publications majeures

• E. Guegain., J. P. Michel, T. Boissenot, J. Nicolas, Tunable Degradation of Copolymers Prepared by Nitroxide-Mediated Radical Ring-Opening Polymerization and Point-by-Point Comparison with Traditional Polyesters, Macromolecules 51(3), 724-736 (2018)
• J. P. Michel, Y. X. Wang, I. Kiesel, Y. Gerelli and V. Rosilio, Disruption of Asymmetric Lipid Bilayer Models Mimicking the Outer Membrane of Gram-Negative Bacteria by an Active Plasticin, Langmuir 33(41), 11028-11039 (2017).
• J. P. Michel, Y. X. Wang, E. Dé, P. Fontaine, M. Goldmann and V. Rosilio, Charge and aggregation pattern govern the interaction of plasticins with LPS monolayers mimicking the external leaflet of the outer membrane of Gram-negative bacteria.
  Biochimica et Biophysica Acta (BBA) – Biomembranes 1848, 2967-2979 (2015).
• T.T. H. Pham, G. Baratt, P. M. Loiseau, J. P. Michel and M. Saint-Pierre Chazalet, Interactions of antileishmanial drugs with monolayers of lipids used in the development of amphotericin B-miltefosine-loaded nanocochleates», Colloids and Surfaces B: Biointerfaces 106, 224–233 (2013).
• Makky, J. P. Michel, Ph. Maillard et V. Rosilio, Biomimetic liposomes and planar supported bilayers for the assessment of glycodendrimeric porphyrins interaction with an immobilized lectin, Biochimica et Biophysica Acta 1808, 656–666 (2011).
• Makky, J. P. Michel, A. Kasselouri, Ph. Maillard et V. Rosilio, Evaluation of the Specific Interactions between Glycodendrimeric Porphyrins, Free or Incorporated into Liposomes, and Concanavalin A by Fluorescence Spectroscopy, Surface Pressure, and QCM-D Measurements, Langmuir 26, 12761–12768 (2010).
• E. Lacaze, J. P. Michel, M. Alba and M. Goldmann, Planar anchoring and surface melting in smectic A phase, Physical Review Letters 76, 041702 (2007).
• J. P. Michel, I. Ivanovska, M. Gibbons, G. Wuite, C. Schmidt, W. Klug and C. M. Knobler, Nanoindentation studies of full and empty viral capsids and the effects of capsid protein mutations on elasticity and strength, Proceedings of the National Academy of Sciences of the USA 103, 6184-6189 (2006).
• J. P. Michel, E. Lacaze, M. Alba, M. de Boissieu, M. Gailhanou and M. Goldmann, Structure of smectic defect cores: x-ray study of 8CB liquid crystal ultrathin film, Physical Review Letters 96, 027803 (2006).
• J. P. Michel and E. Lacaze, M. Alba, M. de Boissieu, M. Gailhanou and M. Goldmann, Optical gratings formed in thin smectic films frustrated on a single crystalline substrate, Physical Review E 70, 011709, 12 pages (2004).