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Gilles Ponchel est Professeur de Biopharmacie et de Technologie Pharmaceutique à l’Université Paris-Sud / Université Paris-Saclay, France. Il dirige actuellement une équipe de recherche dont l’objectif est de « comprendre et améliorer le franchissement des barrières biologiques au moyen de systèmes d’administration innovants » Les axes principaux sont: (i) l’identification des barrières biologiques, y compris les barrières épithéliales et immunitaires, (ii) la compréhension de leur impact sur la délivrance de médicaments et pharmacocinétique et (iii) la conception de nanomédicaments ou de systèmes d’administration innovants capables de contourner ces barrières. Gilles Ponchel est largement connu pour ses travaux visant à mettre à profit le phénomène de mucoadhésion dans l’administration des médicaments. Il a joué un rôle de pionnier dans l’élucidation des mécanismes biophysiques complexes par lesquels les nanoparticules interagissent dynamiquement avec la membrane intestinale. Gilles Ponchel s’intéresse actuellement à comprendre l’impact de la géométrie (formes non sphériques) et de la topologie moléculaire de surface des nanomédecines multifonctionnelles, sur leur comportement pharmacocinétique ADME. Enfin, un des intérêts de Gilles Ponchel est de favoriser le transfert de l’innovation vers l’industrie pharmaceutique.

Gilles Ponchel is a full professor in Biopharmacy and Pharmaceutical Technology at the Université Paris-Sud/Université Paris-Saclay, France. He is currently heading a research group focused on the «Understanding and Crossing of Biological Barriers », and more specifically on the : (i) identification of biological barriers, including epithelial and immune barriers, (ii) understanding of their impact in drug delivery and pharmacokinetics and (iii) design of innovative drug delivery systems, including nanomedicines and able to by-pass these barriers. including, carefully engineered nanomedicines made of tailored polymers, proteins, cyclodextrins, lipids. Gilles Ponchel is world-renowned in the field of mucosal and bioadhesive drug delivery systems. He has had a pioneering role in elucidating the complex biophysical mechanisms by which nanoparticles interact dynamically with the intestinal membrane. The application of his discoveries concerning the phenomena of mucoadhesion made it possible to envisage the oral delivery of certain active molecules whereas it was held until now impossible by this route. More recently, Gilles Ponchel focused on the combined role of the morphology (shape) and the surface molecular topology of nanomedicine on their ADME pharmacokinetic behavior. He is convinced that only the understanding and mastery of the phenomena of recognition (or non-recognition) of biological entities will make possible a full use of the potential of nanomedicine. Finally, Gilles Ponchel is actively involved the transfer of innovation to the pharmaceutical industry.

Mots clés

Biopharmacie, voie orale, perméabilité tissulaires, mucoadhésion, nanoparticules, nanomédecines

Biopharmacy, mucosal routes, tissular permeabilities, mucoadhesion, nanomedicines, nanoparticles

10 publications majeures

• Mendes C, Meirelles G.C., Silva M.A., Ponchel G. (2018). Intestinal permeability determinants of norfloxacin in Ussing chamber model. Eur. J. Pharm. Sci 2018, 121, 236-242.
• Mendes C, Meirelles G.C, Barp C.G, Assreuy J, Silva M.A, Ponchel G. Cyclodextrin based nanosponge of norfloxacin: Intestinal permeation enhancement and improved antibacterial activity. Carbohyd. Polym.. 2018, 195, 586-592.
• Mamadou G, Charrueau C, Dairou J, Limas Nzouzi N, Eto B and Ponchel G. Increased intestinal permeation and modulation of presystemic metabolism of 1 resveratrol formulated into self – emulsifying drug delivery systems. Int. J. Pharm., 2017, 521(1-2), 150-155.
• Palacio H, Otálvaro F, Giraldo L.F, Ponchel G, Segura-Sánchez F. Chitosan-acrylic polymeric nanoparticles with dynamic covalent bonds. Synthesis and stimuli behavior. Chem. Pharm. Bull. 2017;65(12):1132-1143.
• Ponchel G, Cauchois O. Shape-controlled nanoparticles for drug delivery and targeting applications. In Polymer Nanoparticles for Nanomedicines. 2016; pp. 159-184. Springer International Publishing, Suisse, pp1-641, 2016. DOI 10.1007/978-3-319-41421-8_6
• Calleja P, Espuelas S, Vauthier C, Ponchel G, Irache J.M. Controlled release, intestinal transport, and oral bioavailablity of paclitaxel can be considerably increased using suitably tailored pegylated poly (anhydride) nanoparticles. J. Pharm. Sci. 2015;104(9): 2877-2886.
• de Miguel L, Cebrián-Torrejón G, Caudron E, Arpinati L, Doménech-Carbó A, Ponchel G. Bone-targeted cisplatin-complexed poly(?-benzyl-l-glutamate)–poly(glutamic acid) block polymer nanoparticles: An electrochemical approach. ChemElectroChem. 2015;2(5):748-754.
• de Miguel L, Popa I, Noiray M, Caudron E, Arpinati L, Desmaele D, Ponchel G. Osteotropic polypeptide nanoparticles with dual hydroxyapatite binding properties and controlled cisplatin delivery. Pharm. Res. 2015;32(5):1794-1803.
• Bouchemal K, Aka-Any-Grah A, Dereuddre-Bosquet N, Martin L, Lievin-Le-Moal V, Le Grand R, Nicolas V, Gibellini D, Lembo D, Poüs C, Koffi A, Ponchel G. Thermosensitive and mucoadhesive pluronic®/hydroxypropylmethylcellulose hydrogel containing the mini CD4 M48U1 is a promising efficient barrier against HIV diffusion through macaque cervico-vaginal mucus. Antimicrobial Agents and Chemotherapy. 2015;59(4) 2215-2222 https://doi.org/10.1128/AAC.03503-14
• Mazzaferro S, Bouchemal K, Skanji R, Gueutin C, Chacun H, Ponchel G. Intestinal permeation enhancement of docetaxel encapsulated into methyl-beta-cyclodextrin/poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan J. Controlled Rel., 2013, 162(3), 568-574.