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Après avoir obtenu un diplôme d’ingénieur en biotechnologie de l’École Nationale Supérieure de Technologie des Biomolécules de Bordeaux (ENSTBB), Francois Fay a réalisé de 2006 à 2010, une thèse à la Faculté de Pharmacie de Queen’s University Belfast (Royaume-Uni) dans le laboratoire du Prof. Chris Scott. A Queen’s University, ses travaux ont porté sur le développement de nanoparticules polymériques bioactives destinées à améliorer les traitements de l’inflammation et du cancer. En 2012, il a rejoint le laboratoire du Prof. Willem Mulder au sein du Translational and Molecular Imaging Institute à Mount Sinai School of Medicine (NYC, USA). A Mount Sinai sous la direction des professeurs W.J. Mulder et Z.A. Fayad, ses recherches postdoctorales ont porté sur la formulation de nanoparticules biomimétiques et leurs applications dans des modèles d’athérosclérose et de cancer. En 2016, il est nommé Assistant Professor dans le Département de Chimie et de Sciences Pharmaceutiques du York College of The City University of New York. Depuis septembre 2018, Dr. Fay est maitre de conférences à l’Institut Galien de la Faculté de Pharmacie de l’Université Paris-Saclay, où il développe des nanotechnologies bio-inspirées pour des applications biomédicales. De même il s’intéresse au développement de nouvelles méthodes quantitatives pour mesurer la stabilité, la biodistribution, la pharmacocinétique et l’efficacité thérapeutique des formulations pharmaceutiques.

After graduating with a master’s in biotechnology from the École Nationale Supérieure de Technologie des Biomolécules de Bordeaux at University of Bordeaux, Francois Fay completed is PhD at the School of Pharmacy at Queen’s University Belfast (UK) in Prof. Chris Scott’s lab. At Queen’s University, he worked on the development of bioactive polymeric nanoparticles to improve inflammation and cancer treatments. In 2012, he joined Prof. Willem Mulder’s lab within the Translational and Molecular Imaging Institute at Mount Sinai School of Medicine (NYC, USA). At Mount Sinai, under Profs. W.J. Mulder and Z.A. Fayad’s direction, his postdoctoral researches focused on the formulation of biomimetic nanoparticles and their applications in atherosclerosis and cancer models. In 2016, he became Assistant Professor in the Department of Chemistry and Pharmaceutical Sciences at York College of The City University of New York. Since September 2018, Dr. Fay is an Assistant Professor (maître de conférences) at the Institut Galien of the Faculté de Pharmacie, Université Paris-Saclay where he develops bio-inspired nanotechnology for biomedical applications. Dr. Fay is also interested in developing new quantitative tools and methods to measure pharmaceutical formulations’ stability, bio-distribution, pharmacokinetic, and therapeutic efficacy.

Mots clés

Nanoparticules, ciblage cellulaire, inflammation, cancers, sepsis

Nanoparticles, cell targeting, inflammation, cancers, sepsis

10 publications majeures

• Japiassu KB, Fay F, Marengo A, Louaguenouni Y, Cailleau C, Denis S, Chapron D, Tsapis N, Nascimento TL, Lima EM, Fattal E. Interplay between mucus mobility and alveolar macrophage targeting of surface-modified liposomes. Journal of Controlled Release, 352, 15-24, 2022 Dec;352:15-24. DOI : 1016/j.jconrel.2022.10.006.
• Fattal, E, Fay, F, Nanomedicine-based delivery strategies for nucleic acid gene inhibitors in inflammatory diseases. Advanced drug delivery reviews, 175, 113809, 2021. Aug;175:11 DOI: 1016/j.addr.2021.05.019
• Senders ML, Meerwaldt AE, van Leent MMT, Sanchez-Gaytan BL, van de Voort JC, Toner YC, Maier A, Klein ED, Sullivan NAT, Sofias AM, Groenen H, Faries C, Oosterwijk RS, van Leeuwen EM, Fay F, […] Fayad ZA, Calcagno C, Strijkers GJ, Mulder WJM. Nat Nanotechnol. 2020, 15(5):398-405. DOI: 10.1038/s41565-020-0642-4
• Binderup T*, Duivenvoorden R*, Fay F*, van Leent MMT, […], Pérez-Medina C, Mulder WJM (* equal contribution). Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species. Sci Transl Med. 2019, 11(506):eaaw7736. DOI: 10.1126/scitranslmed.aaw7736
• Senders ML, Lobatto ME, Soler R, Lairez O, Pérez-Medina C, Calcagno C, Fayad ZA, Mulder WJM, Fay F. Development and Multiparametric Evaluation of Experimental Atherosclerosis in Rabbits. Methods Mol Biol. 2018, 1816:385-400. DOI: 10.1007/978-1-4939-8597-5_30
• Fay F, Hansen L, Hectors SJCG, Sanchez-Gaytan BL, Zhao Y, Tang J, Munitz J, Alaarg A, Braza MS, Gianella A, Aaronson SA, Reiner T, Kjems J, Langer R, Hoeben FJM, Janssen HM, Calcagno C, Strijkers GJ, Fayad ZA, Pérez-Medina C, Mulder WJM. Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging Bioconjug Chem. 2017, 28(5):1413-1421. DOI:10.1021/acs.bioconjchem.7b00086
• Sanchez-Gaytan BL, Fay F, Hak S, Alaarg A, Fayad ZA, Pérez-Medina C, Mulder WJ, Zhao Y. Real-Time Monitoring of Nanoparticle Formation by FRET Imaging. Angew Chem Int Ed Engl. 2017 56(11):2923-2926.DOI: 10.1002/anie.201611288
• Zhao Y, Fay F, Hak S, Manuel Perez-Aguilar J, Sanchez-Gaytan BL, Goode B, Duivenvoorden R, de Lange Davies C, Bjørkøy A, Weinstein H, Fayad ZA, Pérez-Medina C, Mulder WJ. Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy. Nat Commun. 2016, 7:11221. DOI: 10.1038/ncomms11221
• Spence S, Greene MK, Fay F, Hams E, Saunders SP, Hamid U, Fitzgerald M, Beck J, Bains BK, Smyth P, Themistou E, Small DM, Schmid D, O’Kane CM, Fitzgerald DC, Abdelghany SM, Johnston JA, Fallon PG, Burrows JF, McAuley DF, Kissenpfennig A, Scott CJ. Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation. Sci Transl Med. 2015, 7(303):303ra140. DOI: 10.1126/scitranslmed.aab3459
• Sanchez-Gaytan BL*, Fay F*, Lobatto ME*, Tang J, Ouimet M, Kim Y, van der Staay SE, van Rijs SM, Priem B, Zhang L, Fisher EA, Moore KJ, Langer R, Fayad ZA, Mulder WJ. (* equal contribution) HDL-mimetic PLGA nanoparticle to target atherosclerosis plaque macrophages. Bioconjug Chem. 2015, 26(3):443-51. DOI: 10.1021/bc500517k
• Kim Y*, Fay F*, Cormode DP, Sanchez-Gaytan BL, Tang J, Hennessy EJ, Ma M, Moore K, Farokhzad OC, Fisher EA, Mulder WJ, Langer R, Fayad ZA. (* equal contribution) Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics. ACS Nano. 2013, 7(11):9975-83. DOI: 10.1021/nn4039063