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Florence AGNELY est Professeure de Physique Pharmaceutique à l’Université Paris-Saclay. Ingénieure de l’Ecole Supérieure de Physique et de Chimie Industrielles de la ville de Paris (ESPCI), elle a obtenu une thèse de doctorat sous la direction du Dr I. Iliopoulos et du Dr R. Audebert dans le domaine de la physico-chimie des polymères associatifs à l’Université Pierre et Marie Curie. Elle a effectué un séjour post-doctoral dans l’Unité Mixte CNRS-Elf Atochem dirigée par le Dr L. Leibler (Levallois-Perret, France). Elle dirige actuellement l’équipe Physique Pharmaceutique de l’Institut Galien Paris-Saclay. Ses activités de recherche portent sur la conception et la caractérisation de systèmes à base de polymères et de systèmes émulsionnés pour des applications pharmaceutiques et biomédicales. Elle est co-responsable du parcours de Master 2 Pharmacotechnie et biopharmacie de l’Université Paris-Saclay et membre du bureau du Groupe Formulation de la Société Chimique de France.

Florence AGNELY is Professor of Pharmaceutical Physics at the University Paris-Saclay. Graduated from the Ecole Supérieure de Physique et de Chimie Industrielles de la ville de Paris (ESPCI), she obtained a PhD on the physical chemistry of associating polymers from Pierre et Marie Curie University under the supervision of Dr I. Iliopoulos and Dr R. Audebert. She worked as a post-doc researcher at the joint CNRS-Elf Atochem research unit headed by Dr L. Leibler (Levallois Perret, France). She currently supervises the “Physical Pharmacy” team at the Institut Galien Paris-Saclay. Her research activities are devoted to the design and characterisation of polymer-based systems and of emulsions for pharmaceutical or biomedical applications. She is in charge of the master program « Pharmaceutical Technology and Biopharmacy » of the University Paris-Saclay and is board member of the Formulation Group of the French Chemical Society.

Mots clés

Gels ; biopolymères ; émulsions ; colloïdes ; rhéologie ; formes à libération prolongée

gels; biopolymers; emulsions; colloids; rheology; sustained release dosage forms routes

10 publications majeures

• C. Albert, N. Huang , N. Tsapis, S. Geiger, V. Rosilio, G. Mekhloufi, D. Chapron, B. Robin, M. Beladjine, V. Nicolas, E. Fattal, F. Agnely. Bare and sterically stabilized PLGA nanoparticles for the stabilization of Pickering emulsions. Langmuir, 2018. DOI: 10.1021/acs.langmuir.8b02558
• N. El Kechai, S. Geiger, A. Fallacara, I. Cañero Infante, V. Nicolas, E. Ferrary, N. Huang, A. Bochot, F. Agnely. Mixtures of Hyaluronic Acid and Liposomes in Aqueous Media: Phase Behavior: Microstructure and Mobility of Liposomes. International Journal of Pharmaceutics, 2017, 523, 246-259.
• A. Ali, G. Mekhloufi, N. Huang, F. Agnely. ß-lactoglobulin stabilized nanemulsions – Formulation and process factors affecting droplet size and nanoemulsion stability. International Journal of Pharmaceutics, 2016, 500,291-304.
• N. El Kechai, E. Mamelle, Y. Nguyen, N. Huang, V.Nicolas, P. Chaminade, S. Yen-Nicolaÿ, C. Gueutin, B. Granger, E. Ferrary, F. Agnely, A. Bochot. Hyaluronic acid liposomal gel sustains the delivery of a corticoid to the inner ear. Journal of Controlled Release, 2016, 226, 248-57.
• N. El Kechai, A. Bochot, N. Huang, Y. Nguyen, E. Ferrary, F. Agnely. Effect of liposomes on rheological and syringeability properties of hyaluronic acid hydrogels intended for local injection of drugs. International Journal of Pharmaceutics, 2015, 487, 187-196.
• E. Bouyer, G. Mekhloufi, I. Le Potier, T. Du Fou De Kerdaniel, J-L. Grossiord, V. Rosilio, F. Agnely. Stabilization mechanism of oil-in-water emulsions by ß-lactoglobulin and gum Arabic, Journal of Colloid and Interface Science, 2011, 354, 467-47.
• V. Burckbuchler, G. Mekhloufi, A. Paillard Giteau, J. L. Grossiord, S. Huille, F. Agnely, Rheological and syringeability properties of highly concentrated human polyclonal immunoglobulin solutions. European Journal of Pharmaceutics and Biopharmaceutics, 2010, 76, 351-356.
• A.A. Koffi, F. Agnely, M. Besnard, J. Kablan Brou, J.L. Grossiord, G. Ponchel. In vitro and in vivo characteristics of a thermogelling and bioadhesive delivery system intended for rectal administration of quinine in children, European Journal of Pharmaceutics and Biopharmaceutics, 2008, 69, 167-175.
• F. Artzner, S. Geiger, A. Olivier, C. Allais, S. Finet, F. Agnely. Interactions between poloxamers in aqueous solutions: micellization and gelation studied by differential scanning calorimetry, small angle X-ray scattering and rheology, Langmuir, 2007, 23, 5085-5092.
• L. Martinez, F. Agnely, B. Leclerc, J. Siepmann, M. Cotte, S. Geiger, G. Couarraze. Cross-linking of chitosan and chitosan/poly(ethylene oxide) beads: a theoretical treatment, European Journal of Pharmaceutics and Biopharmaceutics, 2007, 67, 339-348.