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Claire SMADJA est Professeure en Nanobiotechnologies à l’Université Paris-Sud (Université Paris-Saclay, France). Après un doctorat en Pharmacochimie moléculaire (Neuropharmacologie Comportementale) à l’Université Paris-Descartes, elle a ensuite effectué un stage post-doctoral au laboratoire de Neuroscience Moléculaire (bbsrc, Babraham Institut, Cambridge UK). Ses activités de recherche actuelles portent sur l’analyse de protéines thérapeutique et plus particulièrement les anticorps monoclonaux par électrophorèse capillaire. Par ailleurs, elle s’intéresse au développement de dispositifs miniaturisés pour la détection de biomarqueurs (laboratoire sur puce, biocapteurs). Dans ce contexte, elle a participé au développement de méthodes innovantes de pré-traitement d’échantillons complexes utilisant les particules magnétiques.

Claire SMADJA is full professor of Nanobiotechnologies at University Paris-Sud (Université Paris-Saclay, France). After her PhD in Molecular Pharmaco-chemistry (behavioral neuropharmacology) at Paris-Descartes University, she continued her post-doctoral research in the laboratory of Molecular Neuroscience at Babraham Insititut (bbsrc), Cambridge, UK. Her actual research activities are focused on therapeutic proteins analysis, particularly monoclonal antibodies by capillary electrophoresis. She also develops miniaturized devices dedicated to biomarkers detection (i.e. lab on chip, biosensors). In this context, she developed innovative methods for sample pre-treatment in complex media based on magnetic nanoparticles.

Mots clés

Dispositifs miniaturisés ; biomarqueurs ; particules magnétiques ; préconcentration ; électrophorèse capillaire, biocapteurs

Miniaturized devices; biomarkers; magnetic particles; pre-treatment; capillary electrophoresis, biosensors

10 publications majeures

• Le-Minh V., Tran.N.T., Makky A., Rosilio V., Taverna M., Smadja C*., Capillary zone electrophoresis-native mass spectrometry for the quality control of therapeutic intact monoclonal antibodies. J. Chromatogr. A 2019, 13;1601:375-384.
• Mai T.D., Hauser P.C., Descroix S., de Lassichère C. C., Taverna M., Smadja C., In-capillary immuno-preconcentration with circulating bio-functionalized magnetic beads for capillary electrophoresis. Anal. Chim. Acta. 2019, 1062:156-164.
• Coty JB, Varenne F, Benmalek A, Garsaa O, Le Potier I, Taverna M, Smadja C, Vauthier C*, Characterization of nanomedicines’ surface coverage using molecular probes and capillary electrophoresis. Eur. J. Pharm. Biopharm. 2018, 130: 48-58.
• T.D. Mai, D. Ferraro, N. Aboud, R. Renaud, M. Serra, N.T. Tran, J.L. Viovy, C. Smadja, S. Descroix and M. Taverna – Single-step immunoassays and microfluidic droplet operation: towards a versatile approach for detection of amyloid-ß peptide-based biomarkers of Alzheimer’s disease – Sensors and Actuators B: Chemical. 2018, 255, 2126-213.5
• Abood A., Smadja C., Taverna M., Herrenknecht C., Hydrophilic interaction liquid chromatography for dalargin separation from its structural analogues and its side products. J. Chromatogr. A. 2017, 1498:155-162
• Aboud N., Ferraro D., Taverna M., Descroix S., Smadja C, Tran N T., Dyneon THV, a fluorinated thermoplastic as a novel material for microchip capillary electrophoresis. Analyst. 2016,141(20):5776-5783
• Jaccoulet E., Boccard J., Taverna M., Santos Azevedos A., Rudaz S., Smadja C., High throughput identification of monoclonal antibodies after compounding by UV spectroscopy coupled to chemometrics analysis. Anal. Bioanal. Chem, 2016, 408(21):5915-24
• T.D. Mai, I. Pereiro, M. Hiraoui, J.L. Viovy, S. Descroix, M. Taverna and C. Smadja – Magneto-immunocapture with on-bead fluorescent labelling of amyloid-ß peptides: towards a microfluidized-bed-based operation – Analyst, 2015, 140, 5891-5900.
• Jaccoulet E, Smadja C, Prognon P, Taverna M. Capillary electrophoresis for rapid identification of monoclonal antibodies for routine application in hospital. Electrophoresis, 2015, 36,17:2050-6.
• Ammar M., Smadja C., Tandjidora D., Azzouz M., Vigneron J., Etcheberry A., Taverna M., Dufour-Gergam E., Biological engineering of chemically functionalized surface: IgG mouse antibodies immobilization, Langmuir. 2014, 27;30(20):5863-72.