Annuaire du laboratoire :

Bertrand FOURNIER

Maître de conférences Physique pharmaceutique
Site internet: Equipe 3 – physique pharmaceutique
Photo de Bertrand FOURNIER

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CV

In French Bertrand FOURNIER est maître de conférences à l’Institut Galien Paris Sud (Université Paris-Saclay, France). Son domaine d’expertise est la caractérisation des systèmes moléculaires par les techniques de diffraction des rayons X. Après avoir obtenu son doctorat en physique en 2010, il travailla en tant que chercheur postdoctoral à la State University of New York at Buffalo (USA) pendant quatre ans. Il y étudia la dynamique photo-induit des complexes à métaux de transition d’intérêt industriel par photo-cristallographie résolue en temps. En 2015, il séjourna au laboratoire CRM2 (université de Lorraine, Nancy) où il travailla sur la caractérisation de matériaux thermo/photo-commutables. Il fût nommé maître de conférences en septembre 2016. Son travail de recherche porte sur l’étude des propriétés structurales et électroniques photo-induites de molécules organiques et de complexes métalliques photo-sensibilisants d’intérêt pharmaceutique. C’est un travail interdisciplinaire nécessitant le recours aux techniques de spectrométrie et à la diffraction des rayons X résolue en temps, ainsi qu’aux calculs théoriques et aux simulations. Bertrand FOURNIER développe également des outils et méthodes pour le traitement/analyse des données obtenues par diffraction RX et pour la validation des modèles expérimentaux.

In English Bertrand FOURNIER is assistant professor at the Institut Galien Paris Sud (Université Paris-Saclay, France). His area of expertise is the characterization of molecular systems using X-ray diffraction techniques. After obtaining his Ph.D. in Physics in 2010, he worked as a postdoctoral researcher at the State University of New York at Buffalo (USA) during four years. He studied the photo-induced dynamics of transition metal complexes of industrial interest by time-resolved photo-crystallography. In 2015, he stayed at the CRM2 laboratory (University of Lorraine, Nancy) where he worked on the characterization of thermo / photo-switchable materials. He was appointed assistant professor in September 2016. His research focuses on the study of the photo-induced structural and electronic properties of organic molecules and photo-sensitizing metal complexes of pharmaceutical interest. It is an interdisciplinary work requiring the use of time-resolved X-ray spectrometry and diffraction techniques, as well as theoretical calculations and simulations. Bertrand FOURNIER also develops tools and methods for the processing / analysis of data obtained by X-ray diffraction and for the validation of experimental models.

Mots clés

In French molécules photo-sensibilisantes; cristallographie résolue en temps; calculs théoriques; modélisation; analyse des données

In English photo-sensitizing molecules; time-resolved crystallography; theoretical calculations; modelization ; data analysis

10 publications majeures

  • B. Fournier, B. Guillot, C. Lecomte, E. C. Escudero-Adán, C. Jelsch A method to estimate statistical errors of properties derived from charge-density modelling Acta Cryst. Section A (2018) 74:170-183 DOI: 10.1107/S2053273318004308
  • N. Casaretto, D. Schaniel, P. Alle, E. Wenger, P. Parois, B. Fournier, E-E. Bendeif, C. Palin, S. Pillet In-house time-resolved photocrystallography on the millisecond timescale using a gated X-ray hybrid pixel area detector Acta Cryst. Section B (2017) 73(4):696-707 DOI: 10.1107/S2052520617009234
  • B. Fournier, J. Sokolow, P. Coppens Analysis of multicrystal pump-probe data sets. II. Scaling of RATIO data sets Acta Cryst. Section A (2016) 72:250-260 DOI: 10.1107/S2053273315024055
  • K. Jarzembska, R. Kaminski, B. Fournier, E. Trzop, J. Sokolow, R. Henning, Y. Chen, P. Coppens Shedding Light on the Photochemistry of Coinage-Metal Phosphorescent Materials: A Time-Resolved Laue Diffraction Study of an Ag-I-Cu-I Tetranuclear Complex Inorg. Chem. (2014) 53(19):10594-10601 DOI: 10.1021/ic501696y
  • B. Fournier, P. Coppens Analysis of multicrystal pump-probe data sets. I. Expressions for the RATIO model Acta Cryst. Section A (2014) 70:514-517 DOI: 10.1107/S2053273314013229
  • A. Makal, J. Benedict, E. Trzop, J. Sokolow, B. Fournier, Y. Chen, J. Kalinowski, T. Graber, R. Henning, P. Coppens Restricted Photochemistry in the Molecular Solid State: Structural Changes on Photoexcitation of Cu(I) Phenanthroline Metal-to-Ligand Charge Transfer (MLCT) Complexes by Time-Resolved Diffraction J. Phys. Chem. Section A (2012) 116(13):3359:3365 DOI: 10.1021/jp300313s
  • S. Domagala, B. Fournier, D. Liebschner, B. Guillot, C. Jelsch An improved experimental databank of transferable multipolar atom models-ELMAM2. Construction details and applications Acta Cryst. Section A (2012) 68:337-351 DOI: 10.1107/S0108767312008197
  • J. Kalinowski, B. Fournier, A. Makal, P. Coppens The LaueUtil toolkit for Laue photocrystallography. II. Spot finding and integration J. Synchrotron Rad. (2012) 19:637-646 DOI: 10.1107/S0909049512022637
  • D. Liebschner, M. Elias, S. Moniot, B. Fournier, K. Scott, C. Jelsch, B. Guillot, C. Lecomte, E. Chabrière Elucidation of the phosphate binding mode of DING proteins revealed by sub-Ångstrom X-ray crystallography JACS (2009) 131(22) :7879-7886 DOI: 10.1021/ja901900y
  • B. Fournier, E-E. Bendeif, B. Guillot, A. Podjarny, C. Lecomte, C. Jelsch Charge density and electrostatic interactions of fidarestat, an inhibitor of human aldose reductase JACS (2009) 131(31):10929–10941 DOI: 10.1021/ja8095015

 

Catégories : Equipe 3 : Physique pharmaceutique
Mis à jour il y a 11 mois.