Annuaire du laboratoire :
Informations
CV
Anaïs Pitto-Barry est nommée en 2021 Chargée de Recherche au CNRS à l’Institut Galien Paris-Saclay (Université Paris-Saclay, France) après avoir obtenu un poste de Professeur Assistant à l’Université de Bradford (Angleterre) en 2019. Elle a obtenu sa thèse en 20012 sous la direction du Prof. Robert Deschenaux à l’Université de Neuchâtel (Suisse), où elle a étudié les activités biologiques ou mésomorphes de dendrimères et métallodendrimères. Elle rejoint les groupes des Profs Rachel O’Reilly FRS et Andrew Dove à l’Université de Warwick avec une bourse post-doctorale du Fonds National Suisse de la Recherche Scientifique pour travailler sur la conception et la caractérisation d’assemblages polymères innovants. Anaïs a également travaillé avec les Profs Nicolas Barry et Peter Sadler FRS sur le développement de composés métalliques pour applications thérapeutiques à l’Université de Warwick et l’Université de Bradford (UK). Ses activités de recherche portent sur la conception de polymères dendronisés utilisés comme cargo pour transporter des complexes organométalliques ou des atomes de bore pour des applications dans le domaine du cancer. Elle est co-auteur de 54 publications dans des journaux à comité de lecture et de 3 brevets.
Anaïs Pitto-Barry was appointed as CNRS Researcher at the Institut Galien Paris-Saclay (Université Paris-Saclay, France) in 2021 after starting her independant scientific career at the University of Bradford (UK) in 2019. Previously, she obtained her PhD degree from the University of Neuchâtel (Switzerland) with Prof. R. Deschenaux where she focused on the mesomorphic or biological properties of dendritic and metallodendritic assemblies. In 2012, she joined the University of Warwick (UK) to work with Profs R.K. O’Reilly and A.P. Dove on the synthesis, self-assembly, and characterisation of polymeric micelles with a Swiss National Science Foundation Fellowship. She then worked with Profs P.J. Sadler FRS and N.P.E. Barry on the applications of metallated compounds at the University of Warwick and the University of Bradford. Her research activities focus on the design of dendronised polymers used as cargo to carry organometallic complexes or boron atoms for cancer applications. She is co-author of 51 peer-reviewed articles in international journals and three patents.
Mots clés
Polymère ; polymérisation contrôlée ; nanoparticules ; prodrogues ; cancer ; bore ; ruthénium ; chimie bioinorganique
Polymer; controlled polymerisation; nanoparticles; prodrugs; cancer; boron; ruthenium; bioinorganic chemistry
Publications
- Laia Rafols, Maria Azmanova, Nathan Perrigault, Patricia Cooper, Steven Shnyder, et al.. Evaluation of indole-based organometallics as transfer hydrogenation catalysts with anticancer activity. Journal of Organometallic Chemistry, 2024, 1013, pp.123168. ⟨10.1016/j.jorganchem.2024.123168⟩. ⟨hal-04572953⟩
- Anaïs Pitto-Barry. Polymeric nanoparticles containing ruthenium complexes for biomedical applications: a minireview on recent developments. ACS Applied Polymer Materials, In press, ⟨10.1021/acsapm.4c00494⟩. ⟨hal-04540338⟩
- Joan Soldevila-Barreda, Andrea Pettenuzzo, Maria Azmanova, Laia Rafols, Amr Attia, et al.. Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half‐Sandwich Ruthenium and Osmium Complexes. Helvetica Chimica Acta, 2023, 106 (8), pp.e202300064. ⟨10.1002/hlca.202300064⟩. ⟨hal-04245105⟩
- Anaïs Pitto-Barry, Joan Soldevila-Barreda, Nicolas Barry, Jonathan A.G. Cox, James Harrison, et al.. Antibiotics. United Kingdom, Patent n° : US2023/0090293A1. 2023. ⟨hal-04262071⟩
- Victoria Nolan, Laia Rafols, James Harrison, Joan Soldevila-Barreda, Marialuisa Crosatti, et al.. Indole-containing arene-ruthenium complexes with broad spectrum activity against antibiotic-resistant bacteria. Current Research in Microbial Sciences, 2022, 3, pp.100099. ⟨10.1016/j.crmicr.2021.100099⟩. ⟨hal-03523550⟩
- Maria Azmanova, Laia Rafols, Patricia Cooper, Colin Seaton, Steven Shnyder, et al.. Anticancer Water-Soluble Organoruthenium Complexes: Synthesis and Preclinical Evaluation. ChemBioChem, 2022, 23 (18), pp.e202200259. ⟨10.1002/cbic.202200259⟩. ⟨hal-03752249⟩
- Maria Azmanova, Anaïs Pitto-Barry. Oxidative stress in cancer therapy: Friend or enemy?. ChemBioChem, In press, 23 (10), pp.e202100641. ⟨10.1002/cbic.202100641⟩. ⟨hal-03523570⟩
- Anaïs Pitto-Barry. Polymers and boron neutron capture therapy (BNCT): a potent combination. Polymer Chemistry, 2021, 12 (14), pp.2035-2044. ⟨10.1039/D0PY01392G⟩. ⟨hal-04954657⟩
- Mary Beth Wandel, Craig A Bell, Jiayi Yu, Maria C Arno, Nathan Z Dreger, et al.. Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering. Nature Communications, 2021, 12 (1), pp.446. ⟨10.1038/s41467-020-20610-5⟩. ⟨hal-04262190⟩
- Maria Azmanova, Joan J Soldevila-Barreda, Hira Bani Hani, Rianne M Lord, Anaïs Pitto-Barry, et al.. Anticancer Activity of Electron‐Deficient Metal Complexes against Colorectal Cancer in vitro Models. ChemMedChem, In press, 14 (22), pp.1887-1893. ⟨10.1002/cmdc.201900528⟩. ⟨hal-03379599⟩
Documents récupérés de l'archive ouverte HAL 
10 publications majeures
- A Pitto-Barry.* Polymers and boron neutron capture therapy (BNCT): A potent combination. Polym. Chem. 2021, 12, 2035
- M. B. Wandel, C. A. Bell, J. Yu, M. C. Arno, N. Z. Dreger, Y.-H. Hsu, A. Pitto-Barry, J. C. Worch, A. P. Dove, and M. L. Becker. Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering. Nat. Commun. 2021, 12, 446
- K. Habas, J. Soldevila-Barreda, M. Azmanova, L. Rafols, A. Pitto-Barry,* D. Anderson,* and N. P. E. Barry.* Evaluation of the toxicity of two electron-deficient half-sandwich complexes against human lymphocytes from healthy individuals. ChemMedChem 2020, 16, 624
- A Pitto-Barry,* and N. P. E. Barry.* Effect of temperature on the nucleation and growth of precious metal nanocrystals. Angew. Chem. Int. Ed. 2019, 131, 18653
- A Pitto-Barry and N. P. E. Barry.* Influence of boron doping on the dynamics of formation of Os metal nanoclusters on graphitic surfaces. Chem. Commun. 2019, 55, 6038
- A. Pitto-Barry, K. Geraki, M. D. Horbury, V. G. Stavros, J. F. W. Mosselmans, R. I. Walton, P. J. Sadler, and N. P. E. Barry. Controlled fabrication of osmium nanocrystals by electron, laser and microwave irradiation and characterisation by microfocus X-ray absorption spectroscopy. Chem. Commun. 2017, 53, 12898
- Y. Wang, A. Pitto-Barry, A. Habtemariam, I. Romero-Canelon, P. J. Sadler, and N. P. E. Barry. Nanoparticles of chitosan conjugated to organo-ruthenium complexes. Inorg. Chem. Front. 2016, 3, 1058
- I. Romero-Canelón, B. Phoenix, A. Pitto-Barry, J. Tran, J. J. Soldevila-Barreda, N. Kirby, S. Green, P. J. Sadler, and N. P. E. Barry. Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT). J. Organomet. Chem. 2015, 796, 17
- A. Pitto-Barry, N. P. E. Barry, V. Russo, B. Heinrich, B. Donnio, B. Therrien, and R. Deschenaux. Designing supramolecular liquid-crystalline hybrids from pyrenyl-containing dendrimers and arene ruthenium metalla-cycles. J. Am. Chem. Soc. 2014, 136, 17616
- N. P. E. Barry, A. Pitto-Barry, I. Romero-Canelón, J. Tran, J. J. Soldevilla-Barreda, I. Hands-Portman, C. J. Smith, N. Kirby, A. P. Dove, R. K. O’Reilly, and P. J. Sadler. Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity. Farady Discussions 2014, 175, 229