Particle and cell engineering for therapeutic applications

The major research topics of the team are:

• Theranostic systems for ultrasound and fluorine MRI
• Chemoembolization
• Particulate systems for local and systemic delivery of anti-inflammatory, anti-cancer and anti-infectious molecules
• Toxicity of biodegradable nanoparticles
• Pulmonary epithelium models

• Synthesis, formulation and biological evaluation of biodegradable polymers
• Drying and spray drying
• Micro and nanoencapsulation for drug delivery and imaging: lipid and polymer systems
• In vitro and in vivo nanotoxicology
• Murine pharmacokinetics after ear, pulmonary or systemic administration of drug-loaded micro or nanoparticles

TOUSSAINT Balthazar - PhD student
JAUDOIN Céline - PhD student
MATHIEU Clélia - PhD student
BODIN Jean-Baptiste - PhD student
TAULEN Maud - PhD student
DAUBA Ambre
PARCHEN Gabriela
PEZZOLI Anna
NGUYEN Van Thi hong
UTHAYAKUMAR Nithurya
BUCK Eloi
EVEN Benjamin
DEGUETTES Quentin
GURCAN Serra
YU Zhibo
COSTAMAGNA Federica
LEFEBVRE Flora
TESSIER Barbara
REYNAUD Franceline
MARENGO Alessandro
PINHEIRO DO NASCIMENTO Ludmila
QUAILLET Marion
BORDAT Alexandre
HOUVENAGEL Sophie
LORSCHEIDER Mathilde
PICHETH Guilherme
BOISSENOT Tanguy
BOULMEDARAT Laila
BOURGEOIS Sandrine
CANIONI Romain
DUFAY Amélie
GOMES DOS SANTOS Ana
HAMOUDI Mounira
LAJAVARDI Laure
GERVELAS Claudia
ROQUES Caroline
SHAKWEH Monjed
SKANJI Rym
SPAGNUL Aurélie
SURACE Claudio
TOUB Nedjma
TRICHARD Laury
YENICE Irem
PISANI Emilia
GOMEZ-GAETE Carolina
DIAZ-LOPEZ Raquel
KHODER Mouhamad
CRUZ Leticia
SANDOLO Chiara
MENARD Nathalie
TAETZ Sebastian
HONNAS Helge
DIOU Odile
AL-SABBAGH Chantal
N'GUESSAN Alain
PHAM Dinh Duy
GRABOWSKI Nadège
GIACALONE Giovana
LEITE-NASCIMENTO Thais
GRIVES Sophie
RUGE Christian
ARAGAO SANTIAGO Leticia
BOHR Adam
EL KECHAI Naila
CALLEJA GONZALES Patricia
SIMON VAZQUEZ Rosana
SAUVAGE Félix
AL-SHAER Walhan
HOUVENAGEL Sophie
LORSCHEIDER Mathilde
UR-REHMAN Mujeeb
MOUSNIER Ludivine
MURA Simona - Post-doctoral Researcher
COSCO Donato

• ITFA : Innovation Thérapeutique : du Fondamental à l’Appliqué

Publications majeures

• Barillet S, Fattal E, Mura S, Tsapis N, Pallardy M, Hillaireau H, Kerdine-Römer S. Immunotoxicity of poly (lactic-co-glycolic acid) nanoparticles: influence of surface properties on dendritic cell activation. Nanotoxicology. 2019 13(5):606-62
• Binderup T, Duivenvoorden R, Fay F, et al. Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species. Science Translational Medicine 2019 11(506) eaaw7736.
• Deschamps F, Isoardo T, Denis S, Tsapis N, Tselikas L, Nicolas V, Paci A, Fattal E, de Baere T, Huang N, Moine L. Biodegradable Pickering emulsions of Lipiodol for liver trans-arterial chemo-embolization. Acta Biomater. 2019 15(87):177-186.
• Lorscheider M, Tsapis N, Ur-Rehman M, Gaudin F, Stolfa I, Abreu S, Mura S, Chaminade P, Espeli M, Fattal E. Dexamethasone palmitate nanoparticles: An efficient treatment for rheumatoid arthritis. J Control Release. 2019 28(296):179-189.
• Bordat A, Boissenot T, Nicolas J, Tsapis N. Thermoresponsive polymer nanocarriers for biomedical applications. Advanced Drug Delivery Reviews 2019 138: 167-192.
• Sauvage F, Fattal E, Al-Shaer W, Denis S, Brotin E, Denoyelle C, Blanc-Fournier C, Toussaint B, Messaoudi S, Alami M, Barratt G, Vergnaud-Gauduchon J. Antitumor activity of nanoliposomes encapsulating the novobiocin analog 6BrCaQ in a triple-negative breast cancer model in mice. Cancer Letter. 2018;432:103–111. doi:10.1016/j.canlet.2018.06.001
• Alshaer W, Hillaireau H, Fattal E. Aptamer-guided nanomedicines for anticancer drug delivery. Advanced Drug Delivery Reviews 2018 134:122-137.
• Deriu M.A, Tsapis N, Noiray M., Grasso G, El Brahmi N, Mignani S, Majoral JP, Fattal E, Danani A. Elucidating the Role of Surface Chemistry on Cationic Phosphorus Dendrimer-siRNA Complexation. Nanoscale 2018, 10(23):10952-10962.
• Alshaer W, Hillaireau H, Vergnaud J, Mura S, Deloménie C, Sauvage F, Ismail S, Fattal E. Aptamer-guided siRNA-loaded nanomedicines for systemic gene silencing in CD-44 expressing murine triple-negative breast cancer model. Journal of Controlled Release, 2018, 271:198-106.
• Picheth G, Houvenagel S, Dejean C, Couture O, Alves de Freitas R, Moine L, Tsapis N. Echogenicity enhancement by end-fluorinated polylactide perfluorohexane nanocapsules: Towards ultrasound-activable nanosystems. Acta Biomaterialia 2017, 64:313-322.
• Houvenagel S, Picheth G, Dejean C, Brûlet A, Chennevière A, Couture O, Huang N, Moine L, Tsapis N. End-chain fluorination of polyesters favors perfluorooctyl bromide encapsulation into echogenic PEGylated nanocapsules. Polymer Chemistry 2017, 78:2559-2570.
• Bohr A, Tsapis N, Andreana I, Chamarat A, Foged C, Delomenie C, Noiray M, El Brahmi N, Majoral J.P, Mignani S, Fattal E. Anti-inflammatory effect of anti-TNF-a siRNA cationic phosphorous dendrimers nanocomplexes administered intranasally in a murine acute lung injury model. Biomacromolecules 2017, 18(8):2379–2388.
• Boissenot T, Bordat A, Larrat B, Varna M, Chacun H, Paci A, Poinsignon V, Fattal E, Tsapis N. Ultrasound-induced mild hyperthermia improves the anticancer efficacy of both Taxol® and paclitaxel-loaded nanocapsules. Journal of Controlled Release 2017, 264:219-222.
• El Kechai N, Mamelle E, Nguyen Y, Huang N, Nicolas V, ChaminadeP, Yen-Nicolaÿ S, Gueutin C, Granger B, FerraryE, Agnely F, Bochot A. Hyaluronic acid liposomal gel sustains delivery of a corticoid to the inner ear. Journal of Controlled Release 2016, 226:248-257.
• Leite Nascimento T, Hillaireau H, Vergnaud J, Rivano M, Deloménie C, Courilleau D, Arpicco S, Hanes J, Fattal E. Hyaluronic acid-conjugated lipoplexes for targeted delivery of siRNA in a murine metastatic lung cancer model. International Journal of Pharmaceutics 2016, 514(1):103-111.
• Santiago L, Hillaireau H, Grabowski N, Mura S, Nascimento T, Dufort S, Coll J.L, Tsapis N, Fattal E. Compared in vivo toxicity in mice of lung delivered biodegradable and non-biodegradable nanoparticles. Nanotoxicology 2016, 10(3):292-302.
• Ruge C, Hillaireau H, Grabowski N, Beck-Broichsitter M, Cañadas O, Tsapis N, Casals C, Nicolas J, Fattal E. Pulmonary surfactant protein A – mediated enrichment of surface-decorated polymeric nanoparticles in alveolar macrophages. Molecular Pharmaceutics 2016, 13(12):4168-4178.
• Boissenot T, Fattal E, Bordat A, Houvenagel S, Valette J, Chacun H, Gueutin C, Tsapis N. Paclitaxel-Loaded PEGylated Nanocapsules of Perfluorooctyl Bromide as Theranostic Agents. European Journal of Pharmaceutics and Biopharmaceutics 2016, 108:136-144.
• Alshaer W, Hillaireau H, Vergnaud J, Ismail S, Fattal E. Functionalizing Liposomes with anti CD44 Aptamer for Selective Targeting of Cancer Cells. Bioconjugate Chemistry 2015, 26:1307-1313.
• Louguet S, Verret V, Bedouet L, Servais E, Pascale F, Wassef M, Labarre D, Laurent A, Moine L. Poly(ethylene glycol) methacrylate hydrolyzable microspheres for transient vascular embolization. Acta Biomaterialia 2014, 10:1194-205.

[zotpress year="2021"]