Multiphase

Team Research Publications Doctoral school PhD theses defended Former members

Group

Permanent staff

Vincent FAIVRE
Vincent FAIVREProfessor
Team Leader
Ali MAKKY
Ali MAKKYAssociate Professor
Jean-Philippe MICHEL
Jean-Philippe MICHELAssociate Professor
François-Xavier LEGRAND
François-Xavier LEGRANDAssistant Professor
Angelina ANGELOVA
Angelina ANGELOVAResearch Director
David CHAPRON
David CHAPRONDesign Engineer
Iléana-Alexandra PAVEL
Iléana-Alexandra PAVELAssistant Professor

Current members

Thelma AKANCHISE
Thelma AKANCHISEPhD student
Céline DELANSAY
Céline DELANSAYPhD student
Maxime Girardon
Maxime GirardonDesign Engineer
Shi-Minh LOO
Shi-Minh LOOPhd student
Fucen LUO
Fucen LUOPhD student
Khatia MERABISHVILI
Khatia MERABISHVILIPhD student
Do Nhu Trang NGUYEN
Do Nhu Trang NGUYENPost-doctoral fellow
Isokjon POZILOV
Isokjon POZILOVPhD student
Md Masudur RAHMAN
Md Masudur RAHMANPhd student
Léa THIBERVILLE
Léa THIBERVILLEPhD student
Dmitriy VERKHOTUROV
Dmitriy VERKHOTUROVPost-doctoral fellow

Research

The assemblies formed are placed under ad hoc conditions to assess their functionality, either as biomimetic models or as delivery systems for the controlled — and potentially targeted — transport of active substances of pharmaceutical or biomedical interest, and, to a lesser extent, for cosmetic or agri-food applications. These supramolecular architectures are mainly studied in the context of infectious, cancerous, or neurodegenerative diseases.

Biomimetic Models

  • Biomimetic models of biological interfaces and membranes

  • Lamellar topologies (e.g., models of the cytoplasmic membrane, bacterial cell wall) or bicontinuous lyotropic phases, particularly those with cubic symmetry (e.g., models of the mitochondrial membrane)

  • Reconstitution of biomolecules (e.g., membrane receptors) or understanding of the mechanisms by which exogenous molecules (antimicrobial peptides, small bioactive compounds, etc.) are incorporated and act

Multicompartment / Multifunctional Systems

The team has recognised expertise in the design of polyphasic, compartmentalised systems based on lipids and water.

  • Liposomes and Isasomes (cubosomes, hexosomes)

  • Cage-like molecules (amphiphilic cyclodextrins) and self-assemblies

  • Anisotropic particles (cochleates, Janus particles)

Combined Products

A portion of the team’s research focuses on combined products, in which the final therapeutic effect relies on the association of a medical device with one or more active pharmaceutical ingredients.

  • Design of polymeric nanoparticles and stimuli-responsive vesicles with photo-dynamic, photo-thermal, and photo-acoustic properties

  • Encapsulation of inorganic nanoparticles with magnetic and hyperthermic properties

  • Surface modification of implantable systems

Analytical and Instrumental Platform

The team has access to a wide range of instruments, including:

  • UV-visible and fluorescence emission spectrophotometers

  • Light scattering instruments

  • Turbidimetry

  • Small- and wide-angle X-ray scattering/diffraction (SAXS/WAXS)

  • Microscopy (dark field, polarised light, Brewster angle, atomic force)

  • Calorimeters (with or without X-ray coupling)

  • Densimeter

  • Blade and drop tensiometers

  • Langmuir film balances

  • Surface potential measuring electrode

  • Electrochemical impedance spectrometer

  • Set-up for electroformation of giant vesicles

  • Quartz crystal microbalance with dissipation monitoring (QCM-D)

  • Goniometer for contact angle measurements

Expertise

The MULTIPHASE team (MULTIscale physical-chemistry for PHArmaceutical SciencEs) focuses its research on the design of supramolecular systems for applications primarily in the pharmaceutical and biomedical fields. The team’s expertise is structured around two complementary research axes:

(i) Interfaces, structure, and thermodynamics of organised supramolecular architectures

  • Design of supramolecular assemblies based on the characterisation of the structural, thermodynamic, and interfacial properties of compounds and materials of interest, mainly lipids and amphiphiles (custom-designed and synthesised, commercially available, or industrially sourced complex mixtures).

  • Determination of phase behaviour, molecular interactions (at interfaces and in bulk), and dynamic processes within the assembled systems, particularly in response to external stimuli (e.g., light or temperature) or upon incorporation of exogenous molecules (therapeutic agents, peptides, etc.), in order to achieve a detailed understanding and control of their behaviour.

(ii) Development of formulation technologies

  • Development of scalable processes to produce nano- and/or microscale dispersions or suspensions. The aim is to establish correlations between the intrinsic properties of raw materials, the critical parameters of the processing methods (mechanical stress, temperature, etc.), and the attributes of the final products.

  • Exploration of alternative formulation approaches to replace organic solvents, including the use of deep eutectic solvents for processing lipophilic compounds and enabling their delivery.

The MULTIPHASE team was created from the merger of the “Surface Physical Chemistry” and “Multiphase Systems Physical Chemistry” groups within the Institut Galien Paris-Saclay. As such, the team’s expertise builds on a multi-scale approach combining a range of complementary analytical techniques.

As part of the CNRS-Formation Entreprises programme, the team also organises training sessions on lipid physical chemistry and lipid-based nanodispersions.

Publications

Major publications

  • AUGIS L., NERBØ REITEN I., FØRDE J. L., CASAS-SOLVAS J.M., SIZUN C., BIZIEN T., RAJKOVIC I., LARQUET E., MICHELET A., COLLOT M., LESIEUR S., HERFINDAL L., LEGRAND F.X., Development of nanoparticles based on amphiphilic cyclodextrins for the delivery of active substances, International Journal of Pharmaceutics, 651, 123723, 2024. doi.org/10.1016/j.ijpharm.2023.123723
  • WU Y., ANGELOV B., DENG Y., FUJINO T., HOSSAIN M. S., DRECHSLER M., ANGELOVA A. Sustained CREB phosphorylation by lipid-peptide liquid crystalline nanoassemblies. Communications Chemistry, 6 (1), 241, 2023. doi.org/10.1038/s42004-023-01043-9
  • CHAPRON D., CHEN J., ZHENG G., ROSILIO V. Organization of the Interfacial Film of Nanoemulsions Stabilized by Porphyrin Derivatives. Langmuir, 39(4), 1364–1372, 2023. doi.org/10.1021/acs.langmuir.2c01621
  • YU H., ANGELOVA A., ANGELOV B., DYETT B., MATTHEWS L., ZHANG Y., EL MOHAMAD M., CAI X., VALIMEHR S., DRUMMOND C. J., ZHAI J. Real-Time pH-Dependent Self-Assembly of Ionisable Lipids from COVID-19 Vaccines and In Situ Nucleic Acid Complexation. Angewandte Chemie, 62(35), 2023 doi.org/10.1002/anie.202304977
  • BRONSTEIN L.-G., TOTH A., CRESSEY P., ROSILIO V., DI MEO F., MAKKY A. Phospholipid–porphyrin conjugates: deciphering the driving forces behind their supramolecular assemblies. Nanoscale, 14 (19), 7387-7407, 2022. doi.org/10.1039/D2NR01158A
  • CRESSEY P., BRONSTEIN L.-G., BENMAHMOUDI R., ROSILIO V., REGEARD C., MAKKY A. Novel liposome-like assemblies composed of phospholipid-porphyrin conjugates with photothermal and photodynamic activities against bacterial biofilms. International Journal of Pharmaceutics, 623, 121915, 2022. doi.org/10.1016/j.ijpharm.2022.121915
  • MEDARD J., SUN X., PINSON J., LI D., MANGENEY C., MICHEL J. P. Electrografting and Langmuir–Blodgett: Covalently Bound Nanometer-Thick Ordered Films on Graphite. Langmuir, 37 (43), 12539–12547, 2021. doi.org/10.1021/acs.langmuir.1c01723
  • ZMERLI I., MICHEL J. P., MAKKY A. Multifunctional polydopamine-based nanoparticles: synthesis, physico-chemical properties and applications for bimodal photothermal/photodynamic therapy of cancer. Multifunctional Materials, 4 (2), 2021. doi.org/10.1088/2399-7532/abf0fa
  • LIPA-CASTRO A., NICOLAS V., ANGELOVA A., MEKHLOUFI G., PROST B., CHERON M., FAIVRE V., BARRATT G. Cochleate formulations of Amphotericin b designed for oral administration using a naturally occurring phospholipid. International Journal of Pharmaceutics, 603, 120688, 2021. doi.org/10.1016/j.ijpharm.2021.120688
  • BENRABAH L., KEMEL K., TWAROG C., HUANG N., SOLGADI A., LAUGEL C., FAIVRE V. Lipid-based Janus nanoparticles for pharmaceutical and cosmetic applications: Kinetics and mechanisms of destabilization with time and temperature. Colloids and Surfaces B: Biointerfaces, 195, 111242, 2020. doi.org/10.1016/j.colsurfb.2020.111242
  • WANG Z., LANDY D., SIZUN C., CEZARD C., SOLGADI A., PRZYBYLSKI C., CHAISEMARTIN L., HERFINDAL L., BARRATT G., LEGRAND F. X. Cyclodextrin Complexation Studies as the First Step for Repurposing of Chlorpromazine. International Journal of Pharmaceutics, 584, 119391, 2020. doi.org/10.1016/j.ijpharm.2020.119391
  • Wu X., Chantemargue B., Di Meo F., Bourgaux C., Chapron D., Trouillas P., Rosilio V. 2019. Experimental and theoretical approaches for deciphering the peculiar behavior of beta-lapachone in lipid monolayers and bilayers, Langmuir; DOI: 10.1021/acs.langmuir.9b02886
  • N’Diaye M., Vergnaud-Gauduchon J., Nicolas V., Faure V., Denis S., Abreu S., Chaminade P., Rosilio V. 2019. Hybrid lipid polymer nanoparticles for combined chemo- and photodynamic therapy, Molecular Pharmaceutics, 16, 4045-4058; DOI: 10.1021/acs.molpharmaceut.9b00797
  • Massiot J., Rosilio V., Makky A. Photo-triggerable liposomal drug delivery systems: From simple porphyrin insertion in the lipid bilayer towards supramolecular assemblies of lipid-porphyrin conjugates, J. Mater. Chem. B, 2019. Doi: 10.1039/c9tb00015a
  • N’Diaye M., Michel J.P., Rosilio V.<, Combined QCM-D and AFM experiments for understanding the formation of hybrid phospholipid-polymer nanoparticles, Phys. Chem. Chem. Phys. 21, 4306-4319, 2019, Doi: 10.1039/C8CP06955G
  • Guegain E., Michel J.P., Boissenot T., Nicolas J. 2018. Tunable Degradation of Copolymers Prepared by Nitroxide-Mediated Radical Ring-Opening Polymerization and Point-by-Point Comparison with Traditional Polyesters, Macromolecules 51(3), 724-736; DOI: 10.1021/acs.macromol.7b02655
  • Massiot J., Rosilio V., Ibrahim N., Yamamoto A., Nicolas V., Konovalov O., Tanaka M., Makky A., Synthesis and characterization of new lipid-porphyrin conjugates as efficient and selective agents for photodynamic therapy of cancers, Chem. Eur. J. 24, 19179-19194, 2018. Doi: 10.1002/chem.201804865
  • Michel J. P., Wang Y. X., Kiesel I., Gerelli Y. and Rosilio V. 2017. Mechanism of disruption of asymmetric lipid bilayer models mimicking the outer membrane of Gram-negative bacteria by an active plasticin, Langmuir 33(41), 11028-11039; DOI: 10.1021/acs.langmuir.7b02864
  • Makky A., Bousset L, Polesel-Maris J, Melki R. 2016. Nanomechanical properties of distinct fibrillar polymorphs of the protein a-synuclein. Scientific Report 2016, 6, 37970. DOI: 10.1038/srep37970 (Recommended by F1000)
  • Essaid D., Rosilio V., Dadhildjian K., Solgadi A., Vergnaud J., Kasselouri A. Chaminade P. 2016. Artificial plasma membrane models based on lipidomic profiling, Biochimica et Biophysica Acta (BBA) – Biomembranes 1858, 2725-2736; DOI: 10.1016/j.bbamem.2016.07.010
  • Michel J. P., Wang Y. X., Dé E., Fontaine P., Goldmann M. and Rosilio V. 2015. Charge and aggregation pattern govern the interaction of plasticins with LPS monolayers mimicking the external leaflet of the outer membrane of Gram-negative bacteria. Biochimica et Biophysica Acta (BBA) – Biomembranes 1848, 2967-2979; DOI: 10.1016/j.bbamem.2015.09.005
  • A. Angelova, B. Angelov, M. Drechsler, S. Lesieur – Neurotrophin delivery using nanotechnology. Drug Discovery Today, 18, 1263–1271, (2013)
  • B. Angelov, A. Angelova, S.K. Filippov, T. Narayanan, M. Drechsler, P. Stepanik, P. Couvreur, S. Lesieur – DNA/fusogenic lipid nanocarrier assembly: millisecond structural dynamics. The Journal of Physical Chemistry Letters, 4, 1959-1964, (2013)
  • T.T.H. Pham, G. Barratt, J.P. Michel, P.M. Loiseau, M. Saint-Pierre Chazalet – Interactions of antileishmanial drugs with monolayers of lipids used in the development of amphotericin B-miltefosine-loaded nanocochleates. Colloids and Surfaces B: Biointerfaces, 106, 224-233, (2013)
  • L.T.C. Tran, S. Lesieur, V. Faivre – Janus nanoparticles: materials, preparation and recent advances in drug delivery. Expert Opinion in Drug Delivery, 11(7), 1061-74, (2014)
  • C. Bourgaux, P. Couvreur – Interaction of anticancer drugs with biomembranes: What can we learn from model membranes? Journal of Controlled Release, 190, 127-138, (2014)
  • E. Lepeltier, C. Bourgaux, P. Couvreur – Nanoprecipitation and the “Ouzo effect”: Application to drug delivery devices. Advanced Drug Delivery Reviews, 71, 86-97, (2014)
  • E. Lepeltier, C. Bourgaux, A. Maksimenko, F. Meneau, V. Rosilio, F. Zouhiri, D. Desmaële, P.Couvreur – Self-assembly of polyisoprenoyl gemcitabine conjugates: influence of supramolecular organization on their biological activity. Langmuir, 30, 6348-6357, (2014)
  • B. Angelov, A. Angelova, S. Filippov, M. Drechsler, P. Stepanek, S. Lesieur – Multicompartment lipid cubic nanoparticles with high protein upload: Millisecond dynamics of formation. ACS Nano, 8, 5216-5226, (2014)
  • H. Marie, L. Lemaire, F. Franconi, S. Lajnef, Y.M. Frapart, V. Nicolas, G. Frébourg, M.Trichet, C. Ménager, S. Lesieur – Superparamagnetic liposomes for MRI monitoring and external magnetic field-induced selective targeting of malignant brain tumors. Advanced Functional Materials, 25, 1258–1269, (2015)
  • M. E. Fernandez-Sanchez, S. Barbier, J. Whitehead, G. Bealle, A. Michel , H. Latorre-Ossa, C. Rey, L. Fouassier, A. Claperon, L. Brullé, E. Girard, N. Servant, T. Rio-Frio, H. Marie, S. Lesieur, C. Housset, J.L. Gennisson, M. Tanter, C. Ménager, S. Fre, S. Robine, E. Farge – Mechanical induction of the tumorigenic b-catenin pathway by tumour growth pressure. Nature, 523, 92-95, (2015) 4,320
  • E. Berbel Manaia, R. Kiatkoski Kaminiski, B. Caetano, V. Briois, L. Chiavacci, C. Bourgaux – Surface modified Mg-doped ZnO QDs for biological imaging. European Journal of Nanomedicine, 7, 109-120, (2015)
  • F. Sauvage, S. Franzè, A. Bruneau, M. Alami, S. Denis, V. Nicolas, S. Lesieur, F.-X. Legrand, G. Barratt, S. Messaoudi, J. Vergnaud-Gauduchon – Formulation and in vitro efficacy of liposomes containing the Hsp90 inhibitor 6BrCaQ in prostate cancer cells. International Journal of Pharmaceutics, 499 (1-2), 101-109, (2016)
  • L. Zerkoune, S. Lesieur, J.L. Putaux, L. Choisnard, A. Gèze, D. Wouessidjewe, B. Angelov, C. Vebert-Nardin, J. Doutch, A. Angelova – Mesoporous self-assembled nanoparticles of biotransesterifiedcyclodextrins and nonlamellar lipids as carriers of water-insoluble substances. Soft Matter, 12, 7539 – 7550, (2016)
  • C.H. Nguyê~n, J.-L. Putaux, G. Santoni, S. Fourmentin, J.-B. Coty, S. Tfaili, L. Choisnard, A. Gèze, D. Wouessidjewe, G. Barratt, S. Lesieur, F.-X. Legrand – New nanoparticles obtained by co-assembly of amphiphilic cyclodextrins and nonlamellar single-chain lipids: Preparation and characterization. International Journal of Pharmaceutics, 532, 444-456, (2017)
  • B. Angelov, A. Angelova – Nanoscale clustering of the neurotrophin receptor TrkB revealed by super-resolution STED microscopy. Nanoscale, 9, 9797–9804, (2017)
  • J.-L. Putaux, C. Lancelon-Pin, F.-X. Legrand, M. Pastrello, L. Choisnard, A. Gèze, C Rochas, D. Wouessidjewe – Self-Assembly of Amphiphilic Biotransesterified ß-Cyclodextrins: Supramolecular Structure of Nanoparticles and Surface Properties. Langmuir, 33, 7917-7928, (2017)
  • T. Truong-Cong, E. Millart, C.T.L. Le Tuyet, H. Amenitsch, G. Frebourg, S. Lesieur, V. Faivre – Scalable Process to produce Lipid-based Compartmented Janus nanoparticles with pharmaceutically approved excipients. Nanoscale, 10, 3654 – 3662, (2018)
  • F. Sauvage, S. Messaoudi, E. Fattal, G. Barratt, J. Vergnaud-Gauduchon – Heat shock proteins and cancer: how can nanomedicine be harnessed? Journal of Controlled Release, 248, 133–143, (2017)
  • E. Millart, S. Lesieur, V. Faivre – Superparamagnetic lipid-based hybrid nanosystems for drug delivery. Expert Opinion in Drug Delivery, 15(5), 523-540, (2018)
  • F. Sauvage, E. Fattal, W. Al-Shaer, S. Denis, E. Brotin, C. Denoyelle, C. Blanc-Fournier, B. Toussaint, S. Messaoudi, M. Alami, G. Barratt, J. Vergnaud-Gauduchon – Antitumor activity of nanoliposomes encapsulating the novobiocin analogue 6BrCaQ in a triple-negative breast cancer model in mice. Cancer Letters, 432, 103-111, (2018).

190 documents

  • Gaëlle Henneré, Patrice Prognon, Françoise Brion, Véronique Rosilio, Ioannis Nicolis. Molecular dynamics simulation of a mixed lipid emulsion model: Influence of the triglycerides on interfacial phospholipid organization. Journal of Molecular Structure: THEOCHEM, 2009, 901 (1-3), pp.174-185. ⟨10.1016/j.theochem.2009.01.020⟩. ⟨hal-03895197⟩
  • Widad Henni-Silhadi, Michel Deyme, Marta Ruiz de Hoyos, Didier Le Cerf, Luc Picton, et al.. Influence of alkyl chains length on the conformation and solubilization properties of amphiphilic carboxymethylpullulans. Colloid and Polymer Science, 2008, 286 (11), pp.1299 - 1305. ⟨10.1007/s00396-008-1896-9⟩. ⟨hal-01866815⟩
  • Widad Henni-Silhadi, Michel Deyme, Martine Boissonnade, Martine Appel, Didier Le Cerf, et al.. Enhancement of the Solubility and Efficacy of Poorly Water-Soluble Drugs by Hydrophobically-Modified Polysaccharide Derivatives. Pharmaceutical Research, 2007, 24 (12), pp.2317 - 2326. ⟨10.1007/s11095-007-9461-7⟩. ⟨hal-01866832⟩
  • Cécile Menez, Philippe P. Legrand, Véronique Rosilio, Sylviane Lesieur, Gillian Barratt. Physicochemical Characterization of Molecular Assemblies of Miltefosine and Amphotericin B. Molecular Pharmaceutics, 2007, ⟨10.1021/mp0601143⟩. ⟨hal-02929439⟩
  • D. Chapron, Mihaela Girtan, J.-Y. Le Pommelec, A. Bouteville. Droplet dispersion calculations for ultrasonic spray pyrolysis depositions. Journal of Optoelectronics and Advanced Materials, 2007, 9 (4), pp.902-906. ⟨hal-02443193⟩
  • Ghania Degobert, Odile Chambin, Amdidouche -Hussein Didja, G. Marti-Mestres, Véronique Rosilio, et al.. Solutions, suspensions et émulsions destinées aux voies orale, parentérale et ophtalmique. Maloine. Pharmacie galénique formulation et technologie pharmaceutique, pp.105-134, 2007. ⟨hal-02059665⟩
  • Cécile Ménez, Philippe P. Legrand, Véronique Rosilio, Sylviane Lesieur, Gillian Barratt. Physicochemical characterization of molecular assemblies of miltefosine and amphotericin B.. Molecular Pharmaceutics, 2006, 4 (2), pp.281-8. ⟨10.1021/mp0601143⟩. ⟨hal-00180717⟩
  • Widad Henni, Michel Deyme, Michel Stchakovsky, Didier Lecerf, Luc Picton, et al.. Aggregation of hydrophobically modified polysaccharides in solution and at the air–water interface. Journal of Colloid and Interface Science, 2005, 281 (2), pp.316 - 324. ⟨10.1016/j.jcis.2004.08.094⟩. ⟨hal-01866850⟩
  • Gilles Lemercier, Magali Alexandre, Chantal Andraud, Laurent Guérin, D. Chapron, et al.. All–optical induction of enantiomer resolution in a racemic mixture of molecules. SPIE's 48th Annual Meeting - The International Symposium on Optical Science and Technology, Society of Photo-Optical Instrumentation Engineers (SPIE), Aug 2003, San Diego, United States. ⟨hal-02002932⟩
  • Aleksandra Apostoluk, David Chapron, Grégory Gadret, Bouchta Sahraoui, Jean-Michel Nunzi, et al.. Quasi-phase-matched gratings printed by all-optical poling in polymer films. Optics Letters, 2002, 27 (22), pp.2028. ⟨10.1364/OL.27.002028⟩. ⟨hal-01988451⟩

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PhD theses defended since 2014

2024
AUGIS Luc Développement de systèmes à base de solvants eutectiques profonds pour la délivrance cutanée d’anti-infectieux hydrophobes
WU Yu Neuroprotective liquid crystalline cubosome and hexosome nanoparticle formulations by self-assembly of plasmalogen lipids and a neurotrophic peptide
2022
BRONSTEIN Louis-Gabriel Nouveaux asssemblages supramoléculaires à base de conjugués de phospholipide-pohyrin pour une thérapie bimodale photodynamique et photothermique des infections bactériennes.
NGUYEN Van Hung Développement de nanoparticules lipidiques pour la chimio-attraction et le ciblage d’Helicobacter pyolori.
2021
ZMERLI Islam Conception et caractérisation de nanoparticules bio-inspirés à effet bimodal pour le traitement du cancer de l’oesophage
LIPA CASTRO Antonio Nanoparticules pour l’administration orale de l’amphotéricine B pour le traitement de la leishmaniose
RAKOTOARISOA Miora Nanovecteurs lipidiques de molécules neuroprotectrices impliquées dans plusieurs mécanismes de regénération
2019
ZHIQIANG Wang Innovative liposomes with double encapsulation properties for the treatment of acute myeloid leukemia
2018
N’DIAYE Marline Formulation de liponanoparticules pour le traitement du rétinoblastome par bithérapie/photodynamique
BODIN-THOMAZO Noémi Formation d’émulsions multiples stables, stimulables et biocompatibless : application à l’encapsulation et au relargage contrôlé de principes actifs
WU Xiao Approche physico-chimique de la formulation bêta lapachone complexée ou non à des cyclodestrines dans des préparations liposomales
MASSIOT Julien Conception de nanomédicaments  photostimulables à base de lipides et porphyrines ou de conjugués lipide porphyrine pour la libération contrôlée de susbstances actives.
2017
MILLART Elodie Nanoparticules lipidiques de type Janus à compartiment superparamagnétique : du procédé de mise en œuvre aux applications théranostiques
2015
ZERKOUNE Leïla Développement de nanovecteurs multicompartimentés à base de cyclodextrines amphiphiles et de lipides pour des applications en nanomédecine
2014
TRAN Le Tuyet Chau Développement de nanodispersions à base de polyoxyglycerides popur la protection de molécules instables. Application au traitement d’ « Helicobacter pylori »

Former members

Post-docs

ELKIHEL Abdechakour
HILBOLD Benoît
CRESSEY Paul
GARNIER Boris
ROUX Rémi
NUNES DA SILVA Marlon
BERBEL MANAIA Eloïsa

PhD students

DAGHILDJIAN Katia
ESSAID Donia
ALLAIN Vanessa
BEN AMARA DALI Wafa
BERNAT Valérie
BUGEAT Simon
CHAHID Bochra
CHEMIN Caroline
GALLOIS-MONTBRUN Delphine
GLIGUEM Hela
LEPELTIER Elise
MARIE Hélène
NGUYEN Van Hung
OUATTARA Modibo
PILI Barbara
PIVETTE Perrine
PLASSAT Vincent
SEQUIER Floriane
TRUONG CONG Tri
TRAN LETUYET Chau
DAGHILDJIAN Katia
ESSAID Donia

Other former members

BARRATT Gillian, Directrice de Recherche CNRS
OLLIVON Michel, Directeur de Recherche CNRS
BOURGAUX Claudie, Chargée de Recherche CNRS
KELLER Gérard, Ingénieur de Recherche CNRS
LEBAS Geneviève, Professeur
DEYME Michel, Maître de Conférence
LESIEUR Sylviane, Directrice de Recherche CNRS
RINGARD Catherine, Maître de Conférence
ROSILIO Véronique, Professeur
VACHON Jean-Jacques, Assistant Ingénieur

Scientific visitors

DENG Yuru
KELLER Sandro
MERTINS Omar

Masters students

AKANCHISE Thelma
AUGIS Luc
BAGANNEE Nawres
BAILLAVOINE Flore
BOU ALIA Ali
BENHMAHMOUDI Reyene
CALDERON JACINTO Rosa
CHOI Minna
CISERAN Cécile
DE BALMANN Lucas
DELMAS Claire
LEGRAND Laura-Elisa
MERABISHVILI Kathia
MONTAGNAC Laura
N’DIAYE Omar
THADASACK Mélanie
TOSI Lou
WU Yu