Improvement of the transport of biologically active drugs
Group
Permanent staff
Current members
Research
The focus of the group is to understand the biological barriers existing from drug delivery to the pharmacological site of action, aiming to develop original delivery systems of biologically active molecules. The major research projects are:
- Studies of the crossing of biological barriers by formulated biologically active molecules.
- Conception of Physiologically Based PharmacoKinetics (PBPK) models aiming to anticipate drug delivery requirements.
- Conception of (bio)degradable nanoparticulate systems decorated with polysaccharides for drug targeting applications
- Conception and development of bioadhesive formulations (oral routes, …).
- Formulation of biologically active molecules by the mean of conventional controlled-release systems.
Expertise
- Pharmaceutical, veterinary, cosmetics and agrochemical formulations.
- Polymers of pharmaceutical interest.
- Chemical modifications of polymers (coupling of ligands, lectins, biologically active molecules…).
- Polymerization of alkylcyanoacrylates.
- Inclusion of biologically active compounds in cyclodextrins.
- Synthesis and characterization of colloidal systems (nanoparticles, micelles…).
- Biopharmaceutical evaluation of new dosage forms for the administration of biologically active compounds (absorption models, bioadhesion and pharmacokinetics).
Elaboration of PBPK models for assisting drug formulation
Publications
Major publications
Chao F-C, Berbel Manaia E., Ponchel G., Hsieh C.-M. A physiologically-based pharmacokinetic model for predicting doxorubicin disposition in multiple tissue levels and quantitative toxicity assessment. Biomedicine & Pharmacotherapy. 168,115636 2023, DOI :10.1016/j.biopha.2023.115636
Marcelino H.R., Solgadi A., Chéron M., Do Egito E.S.T., Ponchel G. Exploring the permeability of Amphotericin B trough serum albumin dispersions and lipid nanocarriers for oral delivery. Int. J. Pharm., 646, 123444, 2023, DOI : 10.1016/j.ijpharm.2023.123444
Diaz-Salmeron R., Cailleau C., Denis S., Ponchel G., Bouchemal K. Hyaluronan nanoplatelets exert an intrinsic anti-inflammatory activity in a rat model of bladder painful syndrome/interstitial cystitis. J. Controlled Rel., 356, 434-447, 2023, DOI :10.1016/j.jconrel.2023.03.014
Lira-Nogueira MCB; Gibson, VP; Nicolas V.; Santos-Magalhaes, NS; Vauthier, C. Defining Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles from the Design of their Surface Architecture. Pharm. Res. 39(6), 1135-1150, 2022, DOI :1007/s11095-022-03202-4
Diaz-Salmeron R., Toussaint B., Cailleau, C., Ponchel G., Bouchemal K., Morphology-Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder. Advanced Nanobiomed Research, 2(5), 2100138, 2022, DOI : 10.1002/anbr.202100138
Hadji H, Bouchemal K. Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems. Adv Drug Deliv Rev.181, 14101, 2022. DOI: 10.1016/j.addr.2021.114101
Hadji H, Bouchemal K. Effect of micro- and nanoparticle shape on biological processes. J Control Release, 342, 93-110, 2022. DOI: 10.1016/j.jconrel.2021.12.032
Lira-Nogueira MCB., Gibson VP., Nicolas V., Santos-Magalhães NS., Vauthier C. Defining Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles from the Design of their Surface Architecture. Pharm. Res. 39(6),1135-1150, 2022, DOI 10.1007/s11095-022-03202-4
Diaz-Salmeron R., Michel J.-P., Hadji H., Gout E., Vivès R., Ponchel G., Bouchemal K., Role of the interactions of soft hyaluronan nanomaterials with CD44 and supported bilayer membranes in the cellular uptake. Colloids and surfaces. B, Biointerfaces, 205, 111916-111916, 2021, DOI:10.1016/j.colsurfb.2021.111916
Diaz-Salmeron R., Da Costa A., Michel J.-P., Ponchel G., Bouchemal K. Real-time visualization of morphology-dependent self-motion of hyaluronic acid nanomaterials in water. Int. J. Pharm. 609, 121172, 2021, DOI : 10.1016/j.ijpharm.2021.121172
- Bénédicte Pradines, Jean-François Gallard, Bogdan I Iorga, Claire Gueutin, Gilles Ponchel, et al.. The unexpected increase of clotrimazole apparent solubility using randomly methylated β-cyclodextrin.. Journal of Molecular Recognition, 2015, 28 (2), pp.96-102. ⟨hal-01121126⟩
- Bénédicte Pradines, Jean-François Gallard, Bogdan I Iorga, Claire Gueutin, Philippe M Loiseau, et al.. Investigation of the complexation of albendazole with cyclodextrins for the design of new antiparasitic formulations.. Carbohydrate Research, 2014, 398, pp.50-55. ⟨hal-01102312⟩
- Laura de Miguel, Magali Noiray, Georgiana Surpateanu, Bogdan I Iorga, Gilles Ponchel. Poly(γ-benzyl-l-glutamate)-PEG-alendronate multivalent nanoparticles for bone targeting.. International Journal of Pharmaceutics, 2014, 460 (1-2), pp.73-82. ⟨10.1016/j.ijpharm.2013.10.048⟩. ⟨hal-00945856⟩
- Kawthar Bouchemal, Justyna Frelichowska, Loïc M Martin, Vanessa Liévin-Le Moal, Roger Le Grand, et al.. Note on the formulation of thermosensitive and mucoadhesive vaginal hydrogels containing the miniCD4 M48U1 as anti-HIV-1 microbicide. International Journal of Pharmaceutics, 2013, 454 (2), pp.649-652. ⟨10.1016/j.ijpharm.2013.02.055⟩. ⟨hal-02530642⟩
- Nathalie Dereuddre-Bosquet, Laurence Morellato-Castillo, Joachim Brouwers, Patrick Augustijns, Kawthar Bouchemal, et al.. MiniCD4 Microbicide Prevents HIV Infection of Human Mucosal Explants and Vaginal Transmission of SHIV162P3 in Cynomolgus Macaques. PLoS Pathogens, 2012, 8 (12), pp.e1003071. ⟨10.1371/journal.ppat.1003071⟩. ⟨cea-02530573⟩
- Khairallah Alhareth, Christine Vauthier, Fanchon Bourasset, Claire Gueutin, Gilles Ponchel, et al.. Conformation of surface-decorating dextran chains affects the pharmacokinetics and biodistribution of doxorubicin-loaded nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics, 2012, 81 (2), pp.453 - 457. ⟨10.1016/j.ejpb.2012.03.009⟩. ⟨hal-03196146⟩
- Silvia Mazzaferro, Kawthar Bouchemal, Jean-François Gallard, Bogdan I Iorga, Monique Cheron, et al.. Bivalent sequential binding of docetaxel to methyl-β-cyclodextrin.. International Journal of Pharmaceutics, 2011, 416 (1), pp.171-180. ⟨10.1016/j.ijpharm.2011.06.034⟩. ⟨hal-00634146⟩
- M C B Lira, N S Santos-Magalhães, V Nicolas, V Marsaud, M P C Silva, et al.. Cytotoxicity and cellular uptake of newly synthesized fucoidan-coated nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics, 2011, 79 (1), pp.162 - 170. ⟨10.1016/j.ejpb.2011.02.013⟩. ⟨hal-03206185⟩
- Freimar Segura-Sanchez, V. Montembault, Laurent Fontaine, Ma Elisa Martinez-Barbosa, Kawthar Bouchemal, et al.. Synthesis and characterization of functionalized poly(γ-benzyl L-glutamate) derivates and corresponding nanoparticles preparation and characterization. International Journal of pharmaceuticsarmaceutics, 2010, 387 (1-2), pp.244-252. ⟨10.1016/j.ijpharm.2009.12.016⟩. ⟨hal-00486979⟩
- Ma. Elisa Martínez‐barbosa, Sandrine Cammas-Marion, Laurent Bouteiller, Christine Vauthier, Gilles Ponchel. PEGylated degradable composite nanoparticles based on mixtures of PEG-b-poly(g-benzyl L-glutamate. Bioconjugate Chemistry, 2009, 20 (8), pp.1490--1496. ⟨10.1021/bc900017c⟩. ⟨hal-01696721⟩
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Doctoral school and Master’s degree
PhD theses defended since 2014
| 2023 | |
|---|---|
| CHAO Fang-Ching |
PBPK modeling of doxorubicin-loaded polymeric nanoparticles : potential for clinical translation |
| 2020 | |
|---|---|
| ZEESHAN Ahmed | Diffusivité de nanomatériaux non-spécifiques dans le mucus intestinal |
| 2018 | |
|---|---|
| TAYLOR An Young | Nanoparticules à base du poly(L-glutamate de g-benzile) pour l’interception et la destruction des cellules tumorales circulantes dans la circulation sanguine. |
| 2017 | |
|---|---|
| SILVA André | Etude de l’état d’agrégation de l’amphotéricine B dans différents systèmes d’administration. |
Former members
Post-docs
BRAVO-OSUNA Irene (2003-2006) – Chercheur, Université Complutense, Madrid, Espagne
CAMMAS-MARION Sandrine (2000-2002) – CR UMR CNRS 6226 , ENSCR, Rennes, France
CHAUVIERRE Cédric (2001-2003) – Chercheur, U 779 INSERM, Le Kremlin-Bicêtre, France
COURNARIE Fabienne (1999-2003) – R&D, Industrie Pharmaceutique, France
DE MARTIMPREY Henri(2005-2008) – R&D, France
FRELISHOWSKA Justyna (2008-2009) – R&D, France
MARTINEZ BARBOSA Maria Elisa (2002-2006) – Enseignant-chercheur, Université de Sonora, Mexique
MOUSSA Fathi – Professeur université Paris sud, France
SEGURA SANCHEZ Freimar – enseignant, Colombie
SOURY Delphine (2002-2005) – en coll avec EQ IV R&D, Industrie Pharmaceutique, France
STAINMESSE Claire (2007-2008) – R&D, Industrie Pharmaceutique, France
ZANDANEL Christelle – Post-Doctorante
PhD students
CHAO Fang-Ching (2020-2023)
COTY Jean-Baptiste (2015-2017)
MALLI Sophia (2017-2019)
MAMADOU Geoffroy
TAYLOR An Young
AKA-ANY-GRAH Sandrine
ALHARETH Khairallah
BERTHOLON-RAJOT Isabelle (2002-2005) – Chercheur, INSERM, Paris, France
PETIT Bénédicte – Suisse
CAUCHOIS Olivier
CHAUVIERRE Cédric (2001-2003) – Chercheur, U 779 INSERM, Le Kremlin-Bicêtre, France
COURNARIE Fabienne (1999-2003) – R&D, Industrie Pharmaceutique, France
DE MARTIMPREY Henri(2005-2008) – R&D, France
DE MIGUEL Laura
FRELISHOWSKA Justyna (2008-2009) – R&D, France
KASBOU Rawa
KOLOSNJAJ Jelena
MARTINEZ BARBOSA Maria Elisa (2002-2006) – Enseignant-chercheur, Université de Sonora, Mexique
MAZZAFERRO Silvia
MOUSSA Fathi – Professeur Université Paris-Saclay, France
RAMON Anne-Laure
SEGURA SANCHEZ Freimar – enseignant, Colombie
SOURY Delphine (2002-2005) – en coll avec EQ IV R&D, Industrie Pharmaceutique, France
STAINMESSE Claire (2007-2008) – R&D, Industrie Pharmaceutique, France
TEUTONICO Donato
Masters students
DEMGNE FOUBI Gisèle Patricia (2024)
DIAZ-SALMERON Raul
HASSANI Leila
COURNARIE Fabienne (1999-2003) – R&D, Industrie Pharmaceutique, France
DE MARTIMPREY Henri(2005-2008) – R&D, France
FRELISHOWSKA Justyna (2008-2009) – R&D, France
MARTINEZ BARBOSA Maria Elisa (2002-2006) – Enseignant-chercheur, Université de Sonora, Mexique
MOUSSA Fathi – Professeur université Paris sud, France
SEGURA SANCHEZ Freimar – enseignant, Colombie
SOURY Delphine (2002-2005) – en coll avec EQ IV R&D, Industrie Pharmaceutique, France
STAINMESSE Claire (2007-2008) – R&D, Industrie Pharmaceutique, France
ZANDANEL Christelle – Post-Doctorante
Other former members
LEDORTZ Clarisse (2022-2023) – Ingénieur de recherche
VAUTHIER Christine (-2022) – Directrice de Recherche CNRS
BOUCHEMAL Kaouthar (-2023) – Maître de Conférences
DUCHENNE Dominique – Professeur émerite
BRAVO-OSUNA Irene (2003-2006) – Chercheur, Université Complutense, Madrid, Espagne
CAMMAS-MARION Sandrine (2000-2002) – Chargée de Recherche CNRS, UMR CNRS 6226 , ENSCR, Rennes, France
Scientific visitors
COTY Jean-Baptiste – Doctorant
MALLI Sophia – Doctorante
MAMADOU Geoffroy – Doctorant
TAYLOR An Young – Doctorant
AKA-ANY-GRAH Sandrine – Doctorante
ALHARETH Khairallah – Doctorant
BERTHOLON-RAJOT Isabelle (2002-2005) – Chercheur, INSERM, Paris, France
PETIT Bénédicte – Doctorante, Suisse
BRAVO-OSUNA Irene (2003-2006) – Chercheur, Université Complutense, Madrid, Espagne
CAMMAS-MARION Sandrine (2000-2002) – CR UMR CNRS 6226 , ENSCR, Rennes, France
CAUCHOIS Olivier – Doctorant
CHAUVIERRE Cédric (2001-2003) – Chercheur, U 779 INSERM, Le Kremlin-Bicêtre, France
COURNARIE Fabienne (1999-2003) – R&D, Industrie Pharmaceutique, France
DE MARTIMPREY Henri(2005-2008) – R&D, France
DE MIGUEL Laura – Doctorante
FRELISHOWSKA Justyna (2008-2009) – R&D, France
HASSANI Leila – Master
KASBOU Rawa – Doctorante
KOLOSNJAJ Jelena – Doctorante
MARTINEZ BARBOSA Maria Elisa (2002-2006) – Enseignant-chercheur, Université de Sonora, Mexique
MAZZAFERRO Silvia – Doctorante
MOUSSA Fathi – Professeur université Paris sud, France
RAMON Anne-laure – Doctorante
SEGURA SANCHEZ Freimar – enseignant, Colombie
SOURY Delphine (2002-2005) – en coll avec EQ IV R&D, Industrie Pharmaceutique, France
STAINMESSE Claire (2007-2008) – R&D, Industrie Pharmaceutique, France
TEUTONICO Donato – Doctorant