Improvement of the transport of biologically active drugs
Group
Permanent staff
Current members
Research
The focus of the group is to understand the biological barriers existing from drug delivery to the pharmacological site of action, aiming to develop original delivery systems of biologically active molecules. The major research projects are:
- Studies of the crossing of biological barriers by formulated biologically active molecules.
- Conception of Physiologically Based PharmacoKinetics (PBPK) models aiming to anticipate drug delivery requirements.
- Conception of (bio)degradable nanoparticulate systems decorated with polysaccharides for drug targeting applications
- Conception and development of bioadhesive formulations (oral routes, …).
- Formulation of biologically active molecules by the mean of conventional controlled-release systems.
Expertise
- Pharmaceutical, veterinary, cosmetics and agrochemical formulations.
- Polymers of pharmaceutical interest.
- Chemical modifications of polymers (coupling of ligands, lectins, biologically active molecules…).
- Polymerization of alkylcyanoacrylates.
- Inclusion of biologically active compounds in cyclodextrins.
- Synthesis and characterization of colloidal systems (nanoparticles, micelles…).
- Biopharmaceutical evaluation of new dosage forms for the administration of biologically active compounds (absorption models, bioadhesion and pharmacokinetics).
Elaboration of PBPK models for assisting drug formulation
Publications
Major publications
Chao F-C, Berbel Manaia E., Ponchel G., Hsieh C.-M. A physiologically-based pharmacokinetic model for predicting doxorubicin disposition in multiple tissue levels and quantitative toxicity assessment. Biomedicine & Pharmacotherapy. 168,115636 2023, DOI :10.1016/j.biopha.2023.115636
Marcelino H.R., Solgadi A., Chéron M., Do Egito E.S.T., Ponchel G. Exploring the permeability of Amphotericin B trough serum albumin dispersions and lipid nanocarriers for oral delivery. Int. J. Pharm., 646, 123444, 2023, DOI : 10.1016/j.ijpharm.2023.123444
Diaz-Salmeron R., Cailleau C., Denis S., Ponchel G., Bouchemal K. Hyaluronan nanoplatelets exert an intrinsic anti-inflammatory activity in a rat model of bladder painful syndrome/interstitial cystitis. J. Controlled Rel., 356, 434-447, 2023, DOI :10.1016/j.jconrel.2023.03.014
Lira-Nogueira MCB; Gibson, VP; Nicolas V.; Santos-Magalhaes, NS; Vauthier, C. Defining Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles from the Design of their Surface Architecture. Pharm. Res. 39(6), 1135-1150, 2022, DOI :1007/s11095-022-03202-4
Diaz-Salmeron R., Toussaint B., Cailleau, C., Ponchel G., Bouchemal K., Morphology-Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder. Advanced Nanobiomed Research, 2(5), 2100138, 2022, DOI : 10.1002/anbr.202100138
Hadji H, Bouchemal K. Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems. Adv Drug Deliv Rev.181, 14101, 2022. DOI: 10.1016/j.addr.2021.114101
Hadji H, Bouchemal K. Effect of micro- and nanoparticle shape on biological processes. J Control Release, 342, 93-110, 2022. DOI: 10.1016/j.jconrel.2021.12.032
Lira-Nogueira MCB., Gibson VP., Nicolas V., Santos-Magalhães NS., Vauthier C. Defining Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles from the Design of their Surface Architecture. Pharm. Res. 39(6),1135-1150, 2022, DOI 10.1007/s11095-022-03202-4
Diaz-Salmeron R., Michel J.-P., Hadji H., Gout E., Vivès R., Ponchel G., Bouchemal K., Role of the interactions of soft hyaluronan nanomaterials with CD44 and supported bilayer membranes in the cellular uptake. Colloids and surfaces. B, Biointerfaces, 205, 111916-111916, 2021, DOI:10.1016/j.colsurfb.2021.111916
Diaz-Salmeron R., Da Costa A., Michel J.-P., Ponchel G., Bouchemal K. Real-time visualization of morphology-dependent self-motion of hyaluronic acid nanomaterials in water. Int. J. Pharm. 609, 121172, 2021, DOI : 10.1016/j.ijpharm.2021.121172
- Raul Diaz-Salmeron, Balthazar Toussaint, Catherine Cailleau, Gilles Ponchel, Kawthar Bouchemal. Morphology-Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder. Advanced NanoBiomed Research, In press, 2 (5), pp.2100138. ⟨10.1002/anbr.202100138⟩. ⟨hal-03562452⟩
- Christelle Zandanel, Gilles Ponchel, Magali Noiray, Christine Vauthier. Nanoparticles facing the gut barrier: retention or mucosal absorption? Mechanisms and dependency to nanoparticle characteristics. International Journal of Pharmaceutics, 2021, pp.121147. ⟨10.1016/j.ijpharm.2021.121147⟩. ⟨hal-03372832⟩
- Raul Diaz-Salmeron, Antonio da Costa, Jean-Philippe Michel, Gilles Ponchel, Kawthar Bouchemal. Real-Time Visualization of Morphology-Dependent Self-Motion of Hyaluronic Acid Nanomaterials in Water.. International Journal of Pharmaceutics, 2021, International Journal of Pharmaceutics, pp.121172. ⟨10.1016/j.ijpharm.2021.121172⟩. ⟨hal-04125373⟩
- Raul Diaz-Salmeron, Jean-Philippe Michel, Hicheme Hadji, Evelyne Gout, Romain. Vivès, et al.. Role of the interactions of soft hyaluronan nanomaterials with CD44 and supported bilayer membranes in the cellular uptake. Colloids and Surfaces B: Biointerfaces, 2021, 205, pp.111916. ⟨10.1016/j.colsurfb.2021.111916⟩. ⟨hal-03270691⟩
- Sophia Malli, Sebastien Pomel, Indira Dennemont, Philippe Loiseau, Kawthar Bouchemal. Combination of amphotericin B and chitosan platelets for the treatment of experimental cutaneous leishmaniasis: Histological and immunohistochemical examinations. Journal of Drug Delivery Science and Technology, 2019, 50, pp.34-41. ⟨10.1016/j.jddst.2018.12.031⟩. ⟨hal-05149146⟩
- Zeeshan Ahmed, Sophia Malli, Raul Diaz-Salmeron, Pierre-Louis Destruel, Antonio da Costa, et al.. New insights on the structure of hexagonally faceted platelets from hydrophobically modified chitosan and α-cyclodextrin. International Journal of Pharmaceutics, 2018, 548 (1), pp.23 - 33. ⟨10.1016/j.ijpharm.2018.06.035⟩. ⟨hal-01880928⟩
- Tiphany Grisin, Christian Bories, Martina Bombardi, Philippe Loiseau, Valérie Rouffiac, et al.. Supramolecular Chitosan Micro-Platelets Synergistically Enhance Anti-Candida albicans Activity of Amphotericin B Using an Immunocompetent Murine Model. Pharmaceutical Research, 2017, 34 (5), pp.1067-1082. ⟨10.1007/s11095-017-2117-3⟩. ⟨hal-02350871⟩
- Giuseppina Musumeci, Isabella Bon, David Lembo, Valeria Cagno, Maria Carla Re, et al.. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Scientific Reports, 2017, 7 (1), ⟨10.1038/srep41018⟩. ⟨hal-02530919⟩
- Claudio Palazzo, Gilles Ponchel, Jean Jacques Vachon, Sarah Villebrun, Florence Agnely, et al.. Obtaining nonspherical poly(alkylcyanoacrylate) nanoparticles by the stretching method applied with a marketed water-soluble film. International Journal of Polymeric Materials and Polymeric Biomaterials, 2017, 66 (8), pp.416 - 424. ⟨10.1080/00914037.2016.1233420⟩. ⟨hal-03199944⟩
- Kawthar Bouchemal, Armelle Aka-Any-Grah, Nathalie Dereuddre-Bosquet, Loïc M Martin, Vanessa Lievin-Le-Moal, et al.. Thermosensitive and mucoadhesive pluronic-hydroxypropylmethylcellulose hydrogel containing the mini-CD4 M48U1 Is a promising efficient barrier against HIV diffusion through macaque Cervicovaginal Mucus. Antimicrobial Agents and Chemotherapy, 2015, 59 (4), pp.2215-2222. ⟨10.1128/AAC.03503-14⟩. ⟨cea-02530843⟩
Powered by HAL 
Doctoral school and Master’s degree
PhD theses defended since 2014
| 2023 | |
|---|---|
| CHAO Fang-Ching |
PBPK modeling of doxorubicin-loaded polymeric nanoparticles : potential for clinical translation |
| 2020 | |
|---|---|
| ZEESHAN Ahmed | Diffusivité de nanomatériaux non-spécifiques dans le mucus intestinal |
| 2018 | |
|---|---|
| TAYLOR An Young | Nanoparticules à base du poly(L-glutamate de g-benzile) pour l’interception et la destruction des cellules tumorales circulantes dans la circulation sanguine. |
| 2017 | |
|---|---|
| SILVA André | Etude de l’état d’agrégation de l’amphotéricine B dans différents systèmes d’administration. |
Former members
Post-docs
BRAVO-OSUNA Irene (2003-2006) – Chercheur, Université Complutense, Madrid, Espagne
CAMMAS-MARION Sandrine (2000-2002) – CR UMR CNRS 6226 , ENSCR, Rennes, France
CHAUVIERRE Cédric (2001-2003) – Chercheur, U 779 INSERM, Le Kremlin-Bicêtre, France
COURNARIE Fabienne (1999-2003) – R&D, Industrie Pharmaceutique, France
DE MARTIMPREY Henri(2005-2008) – R&D, France
FRELISHOWSKA Justyna (2008-2009) – R&D, France
MARTINEZ BARBOSA Maria Elisa (2002-2006) – Enseignant-chercheur, Université de Sonora, Mexique
MOUSSA Fathi – Professeur université Paris sud, France
SEGURA SANCHEZ Freimar – enseignant, Colombie
SOURY Delphine (2002-2005) – en coll avec EQ IV R&D, Industrie Pharmaceutique, France
STAINMESSE Claire (2007-2008) – R&D, Industrie Pharmaceutique, France
ZANDANEL Christelle – Post-Doctorante
PhD students
CHAO Fang-Ching (2020-2023)
COTY Jean-Baptiste (2015-2017)
MALLI Sophia (2017-2019)
MAMADOU Geoffroy
TAYLOR An Young
AKA-ANY-GRAH Sandrine
ALHARETH Khairallah
BERTHOLON-RAJOT Isabelle (2002-2005) – Chercheur, INSERM, Paris, France
PETIT Bénédicte – Suisse
CAUCHOIS Olivier
CHAUVIERRE Cédric (2001-2003) – Chercheur, U 779 INSERM, Le Kremlin-Bicêtre, France
COURNARIE Fabienne (1999-2003) – R&D, Industrie Pharmaceutique, France
DE MARTIMPREY Henri(2005-2008) – R&D, France
DE MIGUEL Laura
FRELISHOWSKA Justyna (2008-2009) – R&D, France
KASBOU Rawa
KOLOSNJAJ Jelena
MARTINEZ BARBOSA Maria Elisa (2002-2006) – Enseignant-chercheur, Université de Sonora, Mexique
MAZZAFERRO Silvia
MOUSSA Fathi – Professeur Université Paris-Saclay, France
RAMON Anne-Laure
SEGURA SANCHEZ Freimar – enseignant, Colombie
SOURY Delphine (2002-2005) – en coll avec EQ IV R&D, Industrie Pharmaceutique, France
STAINMESSE Claire (2007-2008) – R&D, Industrie Pharmaceutique, France
TEUTONICO Donato
Masters students
DEMGNE FOUBI Gisèle Patricia (2024)
DIAZ-SALMERON Raul
HASSANI Leila
COURNARIE Fabienne (1999-2003) – R&D, Industrie Pharmaceutique, France
DE MARTIMPREY Henri(2005-2008) – R&D, France
FRELISHOWSKA Justyna (2008-2009) – R&D, France
MARTINEZ BARBOSA Maria Elisa (2002-2006) – Enseignant-chercheur, Université de Sonora, Mexique
MOUSSA Fathi – Professeur université Paris sud, France
SEGURA SANCHEZ Freimar – enseignant, Colombie
SOURY Delphine (2002-2005) – en coll avec EQ IV R&D, Industrie Pharmaceutique, France
STAINMESSE Claire (2007-2008) – R&D, Industrie Pharmaceutique, France
ZANDANEL Christelle – Post-Doctorante
Other former members
LEDORTZ Clarisse (2022-2023) – Ingénieur de recherche
VAUTHIER Christine (-2022) – Directrice de Recherche CNRS
BOUCHEMAL Kaouthar (-2023) – Maître de Conférences
DUCHENNE Dominique – Professeur émerite
BRAVO-OSUNA Irene (2003-2006) – Chercheur, Université Complutense, Madrid, Espagne
CAMMAS-MARION Sandrine (2000-2002) – Chargée de Recherche CNRS, UMR CNRS 6226 , ENSCR, Rennes, France
Scientific visitors
COTY Jean-Baptiste – Doctorant
MALLI Sophia – Doctorante
MAMADOU Geoffroy – Doctorant
TAYLOR An Young – Doctorant
AKA-ANY-GRAH Sandrine – Doctorante
ALHARETH Khairallah – Doctorant
BERTHOLON-RAJOT Isabelle (2002-2005) – Chercheur, INSERM, Paris, France
PETIT Bénédicte – Doctorante, Suisse
BRAVO-OSUNA Irene (2003-2006) – Chercheur, Université Complutense, Madrid, Espagne
CAMMAS-MARION Sandrine (2000-2002) – CR UMR CNRS 6226 , ENSCR, Rennes, France
CAUCHOIS Olivier – Doctorant
CHAUVIERRE Cédric (2001-2003) – Chercheur, U 779 INSERM, Le Kremlin-Bicêtre, France
COURNARIE Fabienne (1999-2003) – R&D, Industrie Pharmaceutique, France
DE MARTIMPREY Henri(2005-2008) – R&D, France
DE MIGUEL Laura – Doctorante
FRELISHOWSKA Justyna (2008-2009) – R&D, France
HASSANI Leila – Master
KASBOU Rawa – Doctorante
KOLOSNJAJ Jelena – Doctorante
MARTINEZ BARBOSA Maria Elisa (2002-2006) – Enseignant-chercheur, Université de Sonora, Mexique
MAZZAFERRO Silvia – Doctorante
MOUSSA Fathi – Professeur université Paris sud, France
RAMON Anne-laure – Doctorante
SEGURA SANCHEZ Freimar – enseignant, Colombie
SOURY Delphine (2002-2005) – en coll avec EQ IV R&D, Industrie Pharmaceutique, France
STAINMESSE Claire (2007-2008) – R&D, Industrie Pharmaceutique, France
TEUTONICO Donato – Doctorant