The aim of the group is to propose and to develop original administration systems allowing biologically active compounds to cross biological barriers existing between the administration and the active sites. The major research projects are:

• Conception of new polymers designed for the preparation of (bio)degradable nanoparticular systems for drug targeting.
• Conception of bioadhesive formulations (oral routes, …).
• Valorization of biologically active molecules by their formulation in original systems associating polymers and cyclodextrins.
• Studies of the crossing of biological barriers by formulated biologically active molecules.

• Pharmaceutical, veterinary, cosmetics and agrochemical formulations.
• Polymers of pharmaceutical interest.
• Chemical modifications of polymers (coupling of ligands, lectins, biologically active molecules...).
• Polymerization of alkylcyanoacrylates.
• Inclusion of biologically active compounds in cyclodextrins.
• Synthesis and characterization of colloidal systems (nanoparticles, micelles...).
• Biopharmaceutical evaluation of new dosage forms for the administration of biologically active compounds (absorption models, bioadhesion and pharmacokinetics).

VAUTHIER Christine - CNRS Research Director
BOUCHEMAL Kaouthar - Associate Professor
DUCHENNE Dominique - Emeritus Professeur
COTY Jean-Baptiste - PhD student
DIAZ-SALMERON Raul - Master 2 student
MALLI Sophia - PhD student
MAMADOU Geoffroy - PhD student
TAYLOR An Young - PhD student
AKA-ANY-GRAH Sandrine - PhD student
ALHARETH Khairallah - PhD student
BERTHOLON-RAJOT Isabelle (2002-2005) - Chercheur, INSERM, Paris, France
PETIT Bénédicte - PhD student, Suisse
BRAVO-OSUNA Irene (2003-2006) - Chercheur, Université Complutense, Madrid, Espagne
CAMMAS-MARION Sandrine (2000-2002) - CR UMR CNRS 6226 , ENSCR, Rennes, France
CAUCHOIS Olivier - PhD student
CHAUVIERRE Cédric (2001-2003) - Chercheur, U 779 INSERM, Le Kremlin-Bicêtre, France
COURNARIE Fabienne (1999-2003) - R&D, Industrie Pharmaceutique, France
DE MARTIMPREY Henri(2005-2008) - R&D, France
DE MIGUEL Laura - PhD student
FRELISHOWSKA Justyna (2008-2009) - R&D, France
HASSANI Leila - Master
KASBOU Rawa - PhD student
KOLOSNJAJ Jelena - PhD student
MARTINEZ BARBOSA Maria Elisa (2002-2006) - Enseignant-chercheur, Université de Sonora, Mexique
MAZZAFERRO Silvia - PhD student
MOUSSA Fathi - Professeur université Paris sud, France
RAMON Anne-laure - PhD student
SEGURA SANCHEZ Freimar - enseignant, Colombie
SOURY Delphine (2002-2005) - en coll avec EQ IV R&D, Industrie Pharmaceutique, France
STAINMESSE Claire (2007-2008) - R&D, Industrie Pharmaceutique, France
TEUTONICO Donato - PhD student
ZANDANEL Christelle - Post-Doctoral Researcher

TO BE ADDED FOLLOWING THE FORMAT BELOW (environ 10)

• Wu X., Chantemargue B., Di Meo F., Bourgaux C., Chapron D., Trouillas P., Rosilio V. 2019. Experimental and theoretical approaches for deciphering the peculiar behavior of beta-lapachone in lipid monolayers and bilayers, Langmuir; DOI: 10.1021/acs.langmuir.9b02886

• N’Diaye M., Vergnaud-Gauduchon J., Nicolas V., Faure V., Denis S., Abreu S., Chaminade P., Rosilio V. 2019. Hybrid lipid polymer nanoparticles for combined chemo- and photodynamic therapy, Molecular Pharmaceutics, 16, 4045-4058; DOI: 10.1021/acs.molpharmaceut.9b00797

• Massiot J., Rosilio V., Makky A. Photo-triggerable liposomal drug delivery systems: From simple porphyrin insertion in the lipid bilayer towards supramolecular assemblies of lipid-porphyrin conjugates, J. Mater. Chem. B, 2019. Doi: 10.1039/c9tb00015a

• N’Diaye M., Michel J.P., Rosilio V.<, Combined QCM-D and AFM experiments for understanding the formation of hybrid phospholipid-polymer nanoparticles, Phys. Chem. Chem. Phys. 21, 4306-4319, 2019, Doi: 10.1039/C8CP06955G

• Guegain E., Michel J.P., Boissenot T., Nicolas J. 2018. Tunable Degradation of Copolymers Prepared by Nitroxide-Mediated Radical Ring-Opening Polymerization and Point-by-Point Comparison with Traditional Polyesters, Macromolecules 51(3), 724-736; DOI: 10.1021/acs.macromol.7b02655

• Massiot J., Rosilio V., Ibrahim N., Yamamoto A., Nicolas V., Konovalov O., Tanaka M., Makky A., Synthesis and characterization of new lipid-porphyrin conjugates as efficient and selective agents for photodynamic therapy of cancers, Chem. Eur. J. 24, 19179-19194, 2018. Doi: 10.1002/chem.201804865

• Michel J. P., Wang Y. X., Kiesel I., Gerelli Y. and Rosilio V. 2017. Mechanism of disruption of asymmetric lipid bilayer models mimicking the outer membrane of Gram-negative bacteria by an active plasticin, Langmuir 33(41), 11028-11039; DOI: 10.1021/acs.langmuir.7b02864

• Makky A., Bousset L, Polesel-Maris J, Melki R. 2016. Nanomechanical properties of distinct fibrillar polymorphs of the protein a-synuclein. Scientific Report 2016, 6, 37970. DOI: 10.1038/srep37970 (Recommended by F1000)

• Essaid D., Rosilio V., Dadhildjian K., Solgadi A., Vergnaud J., Kasselouri A. Chaminade P. 2016. Artificial plasma membrane models based on lipidomic profiling, Biochimica et Biophysica Acta (BBA) – Biomembranes 1858, 2725-2736; DOI: 10.1016/j.bbamem.2016.07.010

• Michel J. P., Wang Y. X., Dé E., Fontaine P., Goldmann M. and Rosilio V. 2015. Charge and aggregation pattern govern the interaction of plasticins with LPS monolayers mimicking the external leaflet of the outer membrane of Gram-negative bacteria. Biochimica et Biophysica Acta (BBA) - Biomembranes 1848, 2967-2979; DOI: 10.1016/j.bbamem.2015.09.005

[zotpress year="2021"]