Improvement of the transport of biologically active drugs

Team Themes and expertise Publications Doctoral school Theses defended Former members

Group

Permanent staff

Gilles PONCEL
Gilles PONCELProfessor
Team Leader
Eloísa BERBEL MANAIA
Eloísa BERBEL MANAIAAssociate Professor

Current members

Gabriela FAVERAO
Gabriela FAVERAOPhD student

Research

The focus of the group is to understand the biological barriers existing from drug delivery to the pharmacological site of action, aiming to develop original delivery systems of biologically active molecules. The major research projects are:

  • Studies of the crossing of biological barriers by formulated biologically active molecules.
  • Conception of Physiologically Based PharmacoKinetics (PBPK) models aiming to anticipate drug delivery requirements.
  • Conception of (bio)degradable nanoparticulate systems decorated with polysaccharides for drug targeting applications
  • Conception and development of bioadhesive formulations (oral routes, …).
  • Formulation of biologically active molecules by the mean of conventional controlled-release systems.

Expertise

  • Pharmaceutical, veterinary, cosmetics and agrochemical formulations.
  • Polymers of pharmaceutical interest.
  • Chemical modifications of polymers (coupling of ligands, lectins, biologically active molecules…).
  • Polymerization of alkylcyanoacrylates.
  • Inclusion of biologically active compounds in cyclodextrins.
  • Synthesis and characterization of colloidal systems (nanoparticles, micelles…).
  • Biopharmaceutical evaluation of new dosage forms for the administration of biologically active compounds (absorption models, bioadhesion and pharmacokinetics).

Elaboration of PBPK models for assisting drug formulation

Publications

Major publications

Chao F-C, Berbel Manaia E., Ponchel G., Hsieh C.-M.           A physiologically-based pharmacokinetic model for predicting doxorubicin disposition in multiple tissue levels and quantitative toxicity assessment. Biomedicine & Pharmacotherapy. 168,115636 2023, DOI :10.1016/j.biopha.2023.115636

Marcelino H.R., Solgadi A., Chéron M., Do Egito E.S.T., Ponchel G. Exploring the permeability of Amphotericin B trough serum albumin dispersions and lipid nanocarriers for oral delivery. Int. J. Pharm., 646, 123444, 2023, DOI : 10.1016/j.ijpharm.2023.123444

Diaz-Salmeron R., Cailleau C., Denis S., Ponchel G., Bouchemal K. Hyaluronan nanoplatelets exert an intrinsic anti-inflammatory activity in a rat model of bladder painful syndrome/interstitial cystitis. J. Controlled Rel., 356, 434-447, 2023, DOI :10.1016/j.jconrel.2023.03.014

Lira-Nogueira MCB; Gibson, VP; Nicolas V.; Santos-Magalhaes, NS; Vauthier, C. Defining Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles from the Design of their Surface Architecture. Pharm. Res. 39(6), 1135-1150, 2022, DOI :1007/s11095-022-03202-4

Diaz-Salmeron R., Toussaint B., Cailleau, C., Ponchel G., Bouchemal K., Morphology-Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder. Advanced Nanobiomed Research, 2(5), 2100138, 2022, DOI : 10.1002/anbr.202100138

Hadji H, Bouchemal K. Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems. Adv Drug Deliv Rev.181, 14101, 2022. DOI: 10.1016/j.addr.2021.114101

Hadji H, Bouchemal K. Effect of micro- and nanoparticle shape on biological processes. J Control Release, 342, 93-110, 2022. DOI: 10.1016/j.jconrel.2021.12.032

Lira-Nogueira MCB., Gibson VP., Nicolas V., Santos-Magalhães NS., Vauthier C. Defining Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles from the Design of their Surface Architecture. Pharm. Res. 39(6),1135-1150, 2022, DOI 10.1007/s11095-022-03202-4

Diaz-Salmeron R., Michel J.-P., Hadji H., Gout E., Vivès R., Ponchel G., Bouchemal K., Role of the interactions of soft hyaluronan nanomaterials with CD44 and supported bilayer membranes in the cellular uptake. Colloids and surfaces. B, Biointerfaces,  205, 111916-111916, 2021, DOI:10.1016/j.colsurfb.2021.111916

Diaz-Salmeron R., Da Costa A., Michel J.-P., Ponchel G., Bouchemal K. Real-time visualization of morphology-dependent self-motion of hyaluronic acid nanomaterials in water. Int. J. Pharm. 609, 121172, 2021, DOI : 10.1016/j.ijpharm.2021.121172


5 documents

  • Lachlan Alexander, Marat Mamurov, Hiba Khelifa, Nicolas Illy, Philippe Guégan, et al.. Tuning the size of poly(butylene oxide) nanoparticles by microfluidic-assisted nanoprecipitation. Chemical Engineering Journal Advances, 2025, 23, pp.100792. ⟨10.1016/j.ceja.2025.100792⟩. ⟨hal-04850890v2⟩
  • Hicheme Hadji, Catherine Cailleau, Benoit Chassaing, Mickaël Bourge, Gilles Ponchel, et al.. Hyaluronan nanoplatelets exhibit extended residence time compared to spherical and ellipsoidal nanomaterials with equivalent surface potentials and volumes after oral delivery in rats. Biomaterials Science, 2024, 12 (22), pp.5812-5823. ⟨10.1039/D4BM00672K⟩. ⟨hal-04805583⟩
  • Archana Sumohan Pillai, Mohamed Achraf Ben Njima, Yasmine Ayadi, Laurent Cattiaux, Ali Ladram, et al.. Cyclodextrin-based supramolecular nanogels decorated with mannose for short peptide encapsulation. International Journal of Pharmaceutics, 2024, 660, pp.124379. ⟨10.1016/j.ijpharm.2024.124379⟩. ⟨hal-04847001⟩
  • Ahmed Zeeshan, Hicheme Hadji, Hiba Khelifa, Mickael Bourge, Kawthar Bouchemal. Understanding the interplay between surface properties and the aspect ratio of ellipsoidal nanomaterials. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2024, 680, pp.132680. ⟨10.1016/j.colsurfa.2023.132680⟩. ⟨hal-04281942⟩
  • Sophia Malli, Sebastien Pomel, Indira Dennemont, Philippe Loiseau, Kawthar Bouchemal. Combination of amphotericin B and chitosan platelets for the treatment of experimental cutaneous leishmaniasis: Histological and immunohistochemical examinations. Journal of Drug Delivery Science and Technology, 2019, 50, pp.34-41. ⟨10.1016/j.jddst.2018.12.031⟩. ⟨hal-05149146⟩

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Doctoral school and Master’s degree

PhD theses defended since 2014

2023
CHAO Fang-Ching

PBPK modeling of doxorubicin-loaded polymeric nanoparticles : potential for clinical translation
2021
HICHEM Hadji Administration orale de nanoparticules polysaccharidiques : Impact de leurs propriétés de forme et de surface sur la mucoadhésion, la translocation, la capture cellulaire et l’effet anti-inflammatoire dans un modèle murin de maladie intestinale inflammatoire
2020
ZEESHAN Ahmed Diffusivité de nanomatériaux non-spécifiques dans le mucus intestinal
2019
MALLI Sophia Formulations multifonctionnelles pour le traitement des infections parasitaires cutanéo-muqueuses
DIAZ-SALMERON Raul Nano-plaquettes à mobilité dirigée et adhésion amplifiée pour  l’administration locale
2018
TAYLOR An Young Nanoparticules à base du poly(L-glutamate de g-benzile) pour l’interception et la destruction des cellules tumorales circulantes dans la circulation sanguine.
2017
SILVA André Etude de l’état d’agrégation de l’amphotéricine B dans différents systèmes d’administration.
2016
GODEFROY Mamadou Impact des formulations pharmaceutiques sur l’absorption orale des molécules actives et son évaluation au moyen de chambres de Ussing
MARCELINO Henrique Impact de l’état d’agrégation de l’amphotéricine B sur ses propriétés biopharmaceutiques. Mise en œuvre de micro et de nano-transporteurs en vue de son administration orale
2015
XAVIER-JUNIOR Francisco Formulation de systèmes dispersés pour l’administration orale de pacitaxel à base de microémulsion et de nanocapsules mucoadhésives contenant de l’huile de copaiba
2014
PRADINES Bénédicte Hydrogels thermosensibles et mucoadhésifs nouvelles stratégies pour prévenir et traiter les pathogènes au niveau de la muqueuse vaginale

Former members

Post-docs

BRAVO-OSUNA Irene (2003-2006) – Chercheur, Université Complutense, Madrid, Espagne
CAMMAS-MARION Sandrine (2000-2002) – CR UMR CNRS 6226 , ENSCR, Rennes, France
CHAUVIERRE Cédric (2001-2003) – Chercheur, U 779 INSERM, Le Kremlin-Bicêtre, France
COURNARIE Fabienne (1999-2003) – R&D, Industrie Pharmaceutique, France
DE MARTIMPREY Henri(2005-2008) – R&D, France
FRELISHOWSKA Justyna (2008-2009) – R&D, France
MARTINEZ BARBOSA Maria Elisa (2002-2006) – Enseignant-chercheur, Université de Sonora, Mexique
MOUSSA Fathi – Professeur université Paris sud, France
SEGURA SANCHEZ Freimar – enseignant, Colombie
SOURY Delphine (2002-2005) – en coll avec EQ IV R&D, Industrie Pharmaceutique, France
STAINMESSE Claire (2007-2008) – R&D, Industrie Pharmaceutique, France
ZANDANEL Christelle – Post-Doctorante

PhD students

CHAO Fang-Ching (2020-2023)
COTY Jean-Baptiste (2015-2017)
MALLI Sophia (2017-2019)
MAMADOU Geoffroy
TAYLOR An Young
AKA-ANY-GRAH Sandrine
ALHARETH Khairallah
BERTHOLON-RAJOT Isabelle (2002-2005) – Chercheur, INSERM, Paris, France
PETIT Bénédicte – Suisse
CAUCHOIS Olivier
CHAUVIERRE Cédric (2001-2003) – Chercheur, U 779 INSERM, Le Kremlin-Bicêtre, France
COURNARIE Fabienne (1999-2003) – R&D, Industrie Pharmaceutique, France
DE MARTIMPREY Henri(2005-2008) – R&D, France
DE MIGUEL Laura
FRELISHOWSKA Justyna (2008-2009) – R&D, France
KASBOU Rawa
KOLOSNJAJ Jelena
MARTINEZ BARBOSA Maria Elisa (2002-2006) – Enseignant-chercheur, Université de Sonora, Mexique
MAZZAFERRO Silvia
MOUSSA Fathi – Professeur Université Paris-Saclay, France
RAMON Anne-Laure
SEGURA SANCHEZ Freimar – enseignant, Colombie
SOURY Delphine (2002-2005) – en coll avec EQ IV R&D, Industrie Pharmaceutique, France
STAINMESSE Claire (2007-2008) – R&D, Industrie Pharmaceutique, France
TEUTONICO Donato

Masters students

DEMGNE FOUBI Gisèle Patricia (2024)
DIAZ-SALMERON Raul
HASSANI Leila

COURNARIE Fabienne (1999-2003) – R&D, Industrie Pharmaceutique, France
DE MARTIMPREY Henri(2005-2008) – R&D, France
FRELISHOWSKA Justyna (2008-2009) – R&D, France
MARTINEZ BARBOSA Maria Elisa (2002-2006) – Enseignant-chercheur, Université de Sonora, Mexique
MOUSSA Fathi – Professeur université Paris sud, France
SEGURA SANCHEZ Freimar – enseignant, Colombie
SOURY Delphine (2002-2005) – en coll avec EQ IV R&D, Industrie Pharmaceutique, France
STAINMESSE Claire (2007-2008) – R&D, Industrie Pharmaceutique, France
ZANDANEL Christelle – Post-Doctorante

Other former members

LEDORTZ Clarisse (2022-2023) – Ingénieur de recherche
VAUTHIER Christine (-2022) – Directrice de Recherche CNRS
BOUCHEMAL Kaouthar (-2023) – Maître de Conférences
DUCHENNE Dominique – Professeur émerite
BRAVO-OSUNA Irene (2003-2006) – Chercheur, Université Complutense, Madrid, Espagne
CAMMAS-MARION Sandrine (2000-2002) – Chargée de Recherche CNRS, UMR CNRS 6226 , ENSCR, Rennes, France

Scientific visitors

COTY Jean-Baptiste – Doctorant

MALLI Sophia – Doctorante
MAMADOU Geoffroy – Doctorant
TAYLOR An Young – Doctorant
AKA-ANY-GRAH Sandrine – Doctorante
ALHARETH Khairallah – Doctorant
BERTHOLON-RAJOT Isabelle (2002-2005) – Chercheur, INSERM, Paris, France
PETIT Bénédicte – Doctorante, Suisse
BRAVO-OSUNA Irene (2003-2006) – Chercheur, Université Complutense, Madrid, Espagne
CAMMAS-MARION Sandrine (2000-2002) – CR UMR CNRS 6226 , ENSCR, Rennes, France
CAUCHOIS Olivier – Doctorant
CHAUVIERRE Cédric (2001-2003) – Chercheur, U 779 INSERM, Le Kremlin-Bicêtre, France
COURNARIE Fabienne (1999-2003) – R&D, Industrie Pharmaceutique, France
DE MARTIMPREY Henri(2005-2008) – R&D, France
DE MIGUEL Laura – Doctorante
FRELISHOWSKA Justyna (2008-2009) – R&D, France
HASSANI Leila – Master
KASBOU Rawa – Doctorante
KOLOSNJAJ Jelena – Doctorante
MARTINEZ BARBOSA Maria Elisa (2002-2006) – Enseignant-chercheur, Université de Sonora, Mexique
MAZZAFERRO Silvia – Doctorante
MOUSSA Fathi – Professeur université Paris sud, France
RAMON Anne-laure – Doctorante
SEGURA SANCHEZ Freimar – enseignant, Colombie
SOURY Delphine (2002-2005) – en coll avec EQ IV R&D, Industrie Pharmaceutique, France
STAINMESSE Claire (2007-2008) – R&D, Industrie Pharmaceutique, France
TEUTONICO Donato – Doctorant